Sökning: onr:"swepub:oai:DiVA.org:uu-419006" > Sex specific associ...
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000 | 08281naa a2201717 4500 | |
001 | oai:DiVA.org:uu-419006 | |
003 | SwePub | |
008 | 200908s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-161383 | |
009 | oai:prod.swepub.kib.ki.se:141801221 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4190062 URI |
024 | 7 | a https://doi.org/10.1038/s41431-019-0455-92 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1613832 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1418012212 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laskar, Ruhina Su International Agency for Research on Cancer (IARC), Lyon, France4 aut |
245 | 1 0 | a Sex specific associations in genome wide association analysis of renal cell carcinoma. |
264 | c 2019-06-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
338 | a print2 rdacarrier | |
520 | a Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Muller, David C4 aut |
700 | 1 | a Li, Peng4 aut |
700 | 1 | a Machiela, Mitchell J4 aut |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Gaborieau, Valerie4 aut |
700 | 1 | a Foll, Matthieu4 aut |
700 | 1 | a Hofmann, Jonathan N4 aut |
700 | 1 | a Colli, Leandro4 aut |
700 | 1 | a Sampson, Joshua N4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Bacq-Daian, Delphine4 aut |
700 | 1 | a Boland, Anne4 aut |
700 | 1 | a Abedi-Ardekani, Behnoush4 aut |
700 | 1 | a Durand, Geoffroy4 aut |
700 | 1 | a Le Calvez-Kelm, Florence4 aut |
700 | 1 | a Robinot, Nivonirina4 aut |
700 | 1 | a Blanche, Helene4 aut |
700 | 1 | a Prokhortchouk, Egor4 aut |
700 | 1 | a Skryabin, Konstantin G4 aut |
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700 | 1 | a Yeager, Meredith4 aut |
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700 | 1 | a Savic, Slavisau Karolinska Institutet4 aut |
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700 | 1 | a Ljungberg, Börje,d 1949-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001 |
700 | 1 | a Tumkur Sitaram, Raviprakash,d 1974-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)tura0001 |
700 | 1 | a Giles, Graham G4 aut |
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700 | 1 | a Fletcher, Tony4 aut |
700 | 1 | a Koppova, Kvetoslava4 aut |
700 | 1 | a Larsson, Susanna C4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet4 aut |
700 | 1 | a Banks, Rosamonde E4 aut |
700 | 1 | a Selby, Peter J4 aut |
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700 | 1 | a Pharoah, Paul4 aut |
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700 | 1 | a Michael Gaziano, J4 aut |
700 | 1 | a Sesso, Howard D4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Freedman, Neal D4 aut |
700 | 1 | a Huang, Wen-Yi4 aut |
700 | 1 | a Anema, John G4 aut |
700 | 1 | a Kahnoski, Richard J4 aut |
700 | 1 | a Lane, Brian R4 aut |
700 | 1 | a Noyes, Sabrina L4 aut |
700 | 1 | a Petillo, David4 aut |
700 | 1 | a Teh, Bin Tean4 aut |
700 | 1 | a Peters, Ulrike4 aut |
700 | 1 | a White, Emily4 aut |
700 | 1 | a Anderson, Garnet L4 aut |
700 | 1 | a Johnson, Lisa4 aut |
700 | 1 | a Luo, Juhua4 aut |
700 | 1 | a Chow, Wong-Ho4 aut |
700 | 1 | a Moore, Lee E4 aut |
700 | 1 | a Choueiri, Toni K4 aut |
700 | 1 | a Wood, Christopher4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a McKay, James D4 aut |
700 | 1 | a Brown, Kevin M4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Lathrop, Mark G4 aut |
700 | 1 | a Deleuze, Jean-Francois4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Purdue, Mark P4 aut |
700 | 1 | a Scelo, Ghislaineu International Agency for Research on Cancer (IARC), Lyon, France4 aut |
710 | 2 | a Karolinska Institutetb International Agency for Research on Cancer (IARC), Lyon, France4 org |
773 | 0 | t European Journal of Human Geneticsd : Springer Science and Business Media LLCg 27:10, s. 1589-1598q 27:10<1589-1598x 1018-4813x 1476-5438 |
856 | 4 | u https://doi.org/10.1038/s41431-019-0455-9y Fulltext |
856 | 4 | u https://www.nature.com/articles/s41431-019-0455-9.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419006 |
856 | 4 8 | u https://doi.org/10.1038/s41431-019-0455-9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161383 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141801221 |
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