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Sökning: onr:"swepub:oai:DiVA.org:uu-419398" > Education and gastr...

  • Rota, MatteoUniv Brescia, Dept Mol & Translat Med, Viale Europa 11, I-25123 Brescia, Italy.;Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)

Education and gastric cancer risk-An individual participant data meta-analysis in the StoP project consortium

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-04-10
  • WILEY,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-419398
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419398URI
  • https://doi.org/10.1002/ijc.32298DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143713654URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the "Stomach cancer Pooling (StoP) Project". Educational level and household income were used as proxies for the SEP. We estimated pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) across levels of education and household income by pooling study-specific ORs through random-effects meta-analytic models. The relative index of inequality (RII) was also computed. A total of 9,773 GC cases and 24,373 controls from 25 studies from Europe, Asia and America were included. The pooled OR for the highest compared to the lowest level of education was 0.60 (95% CI, 0.44-0.84), while the pooled RII was 0.45 (95% CI, 0.29-0.69). A strong inverse association was observed both for noncardia (OR 0.39, 95% CI, 0.22-0.70) and cardia GC (OR 0.47, 95% CI, 0.22-0.99). The relation was stronger among H. pylori negative subjects (RII 0.14, 95% CI, 0.04-0.48) as compared to H. pylori positive ones (RII 0.29, 95% CI, 0.10-0.84), in the absence of a significant interaction (p = 0.28). The highest household income category showed a pooled OR of 0.65 (95% CI, 0.48-0.89), while the corresponding RII was 0.40 (95% CI, 0.22-0.72). Our collaborative pooled-analysis showed a strong inverse relationship between SEP indicators and GC risk. Our data call for public health interventions to reduce GC risk among the more vulnerable groups of the population. What's new? Gastric cancer is associated with low socioeconomic position but the precise impact of education on gastric cancer risk needs to be quantified. Here the authors provide an updated quantification through the analysis of the Stomach cancer Pooling (StoP) Project, a large international consortium of case-control studies. They observe a similar to 40% decreased risk of gastric cancer among individuals with intermediate/high education status as compared to less educated study subjects. The association was evident regardless of Helicobacter pylori infection, underscoring the need for public health interventions to reduce gastric cancer risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alicandro, GianfrancoUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy.;Italian Natl Inst Stat, Rome, Italy. (författare)
  • Pelucchi, ClaudioUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)
  • Bonzi, RossellaUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)
  • Bertuccio, PaolaUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy.;Univ Milan, Dept Biomed & Clin Sci, Milan, Italy. (författare)
  • Hu, JinfuHarbin Med Univ, Harbin, Peoples R China. (författare)
  • Zhang, Zuo-FengUniv Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA.;Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA. (författare)
  • Johnson, Kenneth C.Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada. (författare)
  • Palli, DomenicoISPRO, Inst Canc Res Prevent & Clin Network, Canc Risk Factors & LifeStyle Epidemiol Unit, Florence, Italy. Peking Univ, Med Informat Ctr, Beijing, Peoples R China. (författare)
  • Ferraroni, MonicaUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)
  • Yu, Guo-Pei (författare)
  • Galeone, CarlottaUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)
  • Lopez-Carrillo, LizbethMexico Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico. (författare)
  • Muscat, JoshuaPenn State Univ, Coll Med, Tobacco Ctr Regulatory Sci, Dept Publ Hlth Sci, Hershey, PA USA. (författare)
  • Lunet, NunoUniv Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Porto, Portugal.;Univ Porto, Inst Saude Publ, EPIUnit, Porto, Portugal. (författare)
  • Ferro, AnaUniv Porto, Inst Saude Publ, EPIUnit, Porto, Portugal. (författare)
  • Ye, WeiminKarolinska Institutet (författare)
  • Plymoth, AmelieKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (författare)
  • Malekzadeh, RezaUniv Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran. (författare)
  • Zaridze, DavidRussian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia. (författare)
  • Maximovitch, DmitryRussian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia. (författare)
  • Kogevinas, ManolisCIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;ISGlobal, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain. (författare)
  • Fernandez de Larrea, NereaCIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Carlos III Hlth Inst, Natl Ctr Epidemiol, Environm & Canc Epidemiol Unit, Madrid, Spain. (författare)
  • Vioque, JesusCIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Miguel Hernandez Univ, FISABIO ISABIAL, Dept Publ Hlth, Alicante, Spain. (författare)
  • Navarrete-Munoz, Eva M.CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Miguel Hernandez Univ, FISABIO ISABIAL, Dept Publ Hlth, Alicante, Spain. (författare)
  • Tsugane, ShoichiroNatl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan. (författare)
  • Hamada, Gerson S.Nikkei Dis Prevent Ctr, Sao Paulo, Brazil. (författare)
  • Hidaka, AkihisaNatl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan. (författare)
  • Pakseresht, MohammadrezaUniv Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran.;Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada.;Univ Leeds, Ctr Epidemiol & Biostat, Nutr Epidemiol Grp, Leeds, W Yorkshire, England. (författare)
  • Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.(Swepub:uu)alwol516 (författare)
  • Hakansson, NiclasKarolinska Institutet (författare)
  • Hernandez-Ramirez, Raul UlisesMexico Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Yale Sch Med, Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA. (författare)
  • Lopez-Cervantes, MalaquiasSecretaria Salud, Direcc Gen Planeac & Desarrollo Salud, Benito Juarez, Mexico. (författare)
  • Ward, MaryNCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA. (författare)
  • Pourfarzi, FarhadUniv Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran.;Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran. (författare)
  • Mu, LinaSUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA. (författare)
  • Kurtz, Robert C.Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA. (författare)
  • Lagiou, AretiUniv West Attica, Sch Hlth Sci, Dept Publ & Community Hlth, Egaleo, Greece. (författare)
  • Lagiou, Pagona (författare)
  • Boffetta, Paolo (författare)
  • Boccia, Stefania (författare)
  • Negri, EvaUniv Milan, Dept Biomed & Clin Sci, Milan, Italy. (författare)
  • La Vecchia, CarloUniv Milan, Dept Clin Sci & Community Hlth, Milan, Italy. (författare)
  • Univ Brescia, Dept Mol & Translat Med, Viale Europa 11, I-25123 Brescia, Italy.;Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.;Italian Natl Inst Stat, Rome, Italy. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: WILEY146:3, s. 671-6810020-71361097-0215

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