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Prognostic Value of...
Prognostic Value of Circulating Microvesicle Subpopulations in Ischemic Stroke and TIA
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- Lundström, Annika (författare)
- Karolinska Institutet
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- Mobarrez, Fariborz (författare)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Rooth, Elisabeth (författare)
- Karolinska Institutet
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- Thalin, Charlotte (författare)
- Karolinska Institutet
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- von Arbin, Magnus (författare)
- Karolinska Inst, Dept Clin Sci, Div Internal Med, Danderyd Univ Hosp, SE-18288 Stockholm, Sweden.
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- Henriksson, Peter (författare)
- Karolinska Institutet
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- Gigante, Bruna (författare)
- Karolinska Institutet
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- Laska, Ann-Charlotte (författare)
- Karolinska Institutet
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- Wallen, Hakan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-01-25
- 2020
- Engelska.
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Ingår i: Translational Stroke Research. - : Springer Science and Business Media LLC. - 1868-4483 .- 1868-601X. ; 11:4, s. 708-719
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Platelet microvesicles (PMV) have previously been found elevated in acute ischemic stroke (IS) and could be biomarkers for risk of recurrence. PMV surface antigens such as P-selectin and phosphatidylserine (PS) reflect platelet activation and procoagulance. Tissue factor-positive microvesicles (TF+MV) are considered procoagulant, in particular if co-expressing PS. We enumerated MV subpopulations with these surface antigens in a cohort of 211 patients with primarily non-cardioembolic IS or transient ischemic attack (TIA) and investigated their association with long-term outcome. MV concentrations were determined by flow cytometry in the acute and convalescent phase. Primary outcome was a composite of fatal and non-fatal recurrent IS or myocardial infarction. Secondary outcomes were recurrent IS and all-cause mortality. Outcome events were obtained from Swedish registers during a follow-up of 1100 patient years. Concentrations of PS-positive and PS-negative MV populations were elevated in patients compared with healthy controls in both the acute and convalescent phase. PS+TF+PMV displayed pronounced elevations, median fold change 77 in the acute phase (p < 0.0001) but were not associated with outcome, neither were PS+P-selectin(+)PMV. The only subpopulation positively associated with primary outcome was PS-TF+PMV, with adjusted hazard ratio of 1.86 (1.04-3.31,p = 0.036) by Cox regression. Unexpectedly, several MV subpopulations tended to be associated with reduced risk of poor long-term outcome. Our results suggest that PS+TF+PMV may be a promising marker for cerebral ischemia, and that the in vivo generation of PS-MV after IS/TIA warrants further study. Future MV studies should ideally enumerate PS(+)and PS-MV subpopulations separately.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Ischemic stroke
- TIA
- Microvesicles
- Platelet
- Phosphatidylserine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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