Sökning: onr:"swepub:oai:DiVA.org:uu-419793" > Reduced intensity c...
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000 | 13776naa a2201357 4500 | |
001 | oai:DiVA.org:uu-419793 | |
003 | SwePub | |
008 | 200916s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:144221407 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4197932 URI |
024 | 7 | a https://doi.org/10.1182/bloodadvances.20190012662 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442214072 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zhou, Zhengu Lahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA.4 aut |
245 | 1 0 | a Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens :b a CIBMTR report |
264 | c 2020-07-14 | |
264 | 1 | b American Society of Hematology,c 2020 |
338 | a print2 rdacarrier | |
520 | a There is a lack of large comparative study on the outcomes of reduced intensity conditioning (RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and fludarabine/melphalan (FM) regimens. Adult AML patients from Center for International Blood and Marrow Transplant Research who received first RIC allo-transplant between 2001 and 2015 were studied. Patients were excluded if they received cord blood or identical twin transplant, total body irradiation in conditioning, or graft-versus-host disease (GVHD) prophylaxis with in vitro T-cell depletion. Primary outcome was overall survival (OS), secondary end points were leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and GVHD. Multivariate survival model was used with adjustment for patient, leukemia, and transplant-related factors. A total of 622 patients received FM and 791 received FB RIC. Compared with FB, the FM group had fewer transplant in complete remission (CR), fewer matched sibling donors, and less usage of anti-thymocyte globulin or alemtuzumab. More patients in the FM group received marrow grafts and had transplantation before 2005. OS was significantly lower within the first 3 months posttransplant in the FM group (hazard ratio [HR] = 1.82, P < .001), but was marginally superior beyond 3 months (HR = 0.87, P = .05). LFS was better with FM compared with FB (HR = 0.89, P = .05). NRM was significantly increased in the FM group during the first 3 months of posttransplant (HR = 3.85, P < .001). Long-term relapse was lower with FM (HR = 0.65, P < .001). Analysis restricted to patients with CR showed comparable results. In conclusion, compared with FB, the FM RIC showed a marginally superior long-term OS and LFS and a lower relapse rate. A lower OS early posttransplant within 3 months was largely the result of a higher early NRM. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Nath, Rajneeshu Banner MD Anderson Canc Ctr, Gilbert, AZ USA.4 aut |
700 | 1 | a Cerny, Janu Univ Massachusetts, Med Ctr, Dept Med, 3Div Hematol Oncol, Worcester, MA USA.4 aut |
700 | 1 | a Wang, Hai-Linu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Zhang, Mei-Jieu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Abdel-Azim, Hishamu Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Ahmed, Gulrayzu Med Coll Wisconsin, Internal Med, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Al-Homsi, A. Sameru NYU, Langone Med Ctr, New York, NY USA.4 aut |
700 | 1 | a Aljurf, Mahmoudu King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a Alkhateeb, Hassan B.u Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA.4 aut |
700 | 1 | a Assal, Ameru NYPH Columbia Univ Med Ctr, New York, NY USA.4 aut |
700 | 1 | a Bacher, Ulrikeu Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.4 aut |
700 | 1 | a Bajel, Ashishu Royal Melbourne Hosp, City Campus, Parkville, Vic, Australia.4 aut |
700 | 1 | a Bashir, Qaiseru Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Battiwalla, Minocheru Sarah Cannon Blood Canc Network, Nashville, TN USA.4 aut |
700 | 1 | a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut |
700 | 1 | a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Cahn, Jean-Yvesu Ctr Hosp Univ Grenoble Alpes, Dept Hematol, Grenoble, France.4 aut |
700 | 1 | a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut |
700 | 1 | a Choe, Hannahu Ohio Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH USA.4 aut |
700 | 1 | a Copelan, Edwardu Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut |
700 | 1 | a Cutler, Coreyu Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.4 aut |
700 | 1 | a Damlaj, Moussab B.u King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a DeFilipp, Zachariahu Massachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.4 aut |
700 | 1 | a De Lima, Marcosu Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.4 aut |
700 | 1 | a Diaz, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut |
700 | 1 | a Farhadfar, Noshau Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut |
700 | 1 | a Foran, Jamesu Mayo Clin, Bone Marrow Transplant Program, Jacksonville, FL 32224 USA.4 aut |
700 | 1 | a Freytes, Cesar O.u Texas Transplant Inst, San Antonio, TX USA.4 aut |
700 | 1 | a Gerds, Aaron T.u Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a Gergis, Usamau New York Presbyterian Hosp, Dept Med Oncol, Hematol Malignancies & Bone Marrow Transplant, Weill Cornell Med Ctr, New York, NY USA.4 aut |
700 | 1 | a Grunwald, Michael R.u Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut |
700 | 1 | a Gul, Zartashu Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA.4 aut |
700 | 1 | a Hamadani, Mehdiu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Hashmi, Shahrukhu Mayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a Hertzberg, Marku Prince Wales Hosp, Dept Haematol, Randwick, NSW, Australia.4 aut |
700 | 1 | a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a Hossain, Nasheedu Loyola Univ Chicago, Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol Oncol, Maywood, IL USA.4 aut |
700 | 1 | a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut |
700 | 1 | a Isola, Luisu Mt Sinai Med Ctr, New York, NY 10029 USA.4 aut |
700 | 1 | a Jain, Taniau Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Kamble, Rammurti T.u Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA.4 aut |
700 | 1 | a Khan, Muhammad Waqasu Louisiana State Univ, Bone Marrow Transplant Program, Div Hematol Oncol, Baton Rouge, LA 70803 USA.4 aut |
700 | 1 | a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut |
700 | 1 | a Kebriaei, Partowu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Kekre, Natashau Ottawa Hosp Blood & Marrow Transplant Program, Ottawa, ON, Canada.4 aut |
700 | 1 | a Khera, Nanditau Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA.4 aut |
700 | 1 | a Lazarus, Hillard M.u Case Western Reserve Univ, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a Liesveld, Jane L.u Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.4 aut |
700 | 1 | a Litzow, Marku Mayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA.4 aut |
700 | 1 | a Liu, Hongtaou Univ Chicago Med, Chicago, IL USA.4 aut |
700 | 1 | a Marks, David, Iu Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.4 aut |
700 | 1 | a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain.4 aut |
700 | 1 | a Mathews, Vikramu Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.4 aut |
700 | 1 | a Mishra, Asmitau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut |
700 | 1 | a Murthy, Hemant S.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut |
700 | 1 | a Nagler, Arnonu Chaim Sheba Med Ctr, Hematol Div, Tel Hashomer, Israel.;Chaim Sheba Med Ctr, BMT, Tel Hashomer, Israel.;Tel Aviv Univ, Div Hematol & Bone Marrow Transplantat, Tel Aviv, Israel.;Tel Aviv Univ, Cord Blood Bank, Tel Aviv, Israel.4 aut |
700 | 1 | a Nakamura, Ryotarou City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.4 aut |
700 | 1 | a Nathan, Sunitau Rush Univ, Med Ctr, Chicago, IL 60612 USA.4 aut |
700 | 1 | a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut |
700 | 1 | a Olin, Rebeccau Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Olsson, Richard F.u Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Palmisiano, Neilu Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA.4 aut |
700 | 1 | a Patel, Sagar S.u Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut |
700 | 1 | a Patnaik, Mrinal M.u Mayo Clin, Bone Marrow Transplant Program, Rochester, MN USA.4 aut |
700 | 1 | a Pawarode, Attapholu Univ Michigan, Sch Med, Dept Internal Med, Div Hematol Oncol,Blood & Marrow Transplantat Pro, Ann Arbor, MI USA.4 aut |
700 | 1 | a Perales, Miguel-Angelu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Politikos, Ioannisu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Popat, Udayu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Rizzieri, Davidu Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.4 aut |
700 | 1 | a Sandmaier, Brenda M.u Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
700 | 1 | a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut |
700 | 1 | a Seo, Sachikou Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan.4 aut |
700 | 1 | a Shah, Nirav N.u Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Uy, Geoffrey L.u Washington Univ, Sch Med, Div Oncol, St Louis, MO USA.4 aut |
700 | 1 | a Valcarcel, Davidu Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain.4 aut |
700 | 1 | a Verdonck, Leo F.u Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.4 aut |
700 | 1 | a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.4 aut |
700 | 1 | a Wang, Youjinu NCI, NIH, Rockville, MD USA.4 aut |
700 | 1 | a Weisdorf, Danielu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Wirk, Baldeepu Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.4 aut |
700 | 1 | a Wong, Ericu Royal Melbourne Hosp, City Campus, Parkville, Vic, Australia.4 aut |
700 | 1 | a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.4 aut |
700 | 1 | a Saber, Waelu Med Coll Wisconsin, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.4 aut |
710 | 2 | a Lahey Hosp & Med Ctr, Beth Israel Lahey Hlth, Burlington, MA 01805 USA.b Banner MD Anderson Canc Ctr, Gilbert, AZ USA.4 org |
773 | 0 | t Blood Advancesd : American Society of Hematologyg 4:13, s. 3180-3190q 4:13<3180-3190x 2473-9529x 2473-9537 |
856 | 4 | u https://ashpublications.org/bloodadvances/article/4/13/3180/461319/Reduced-intensity-conditioning-for-acute-myeloid |
856 | 4 | u https://ashpublications.org/bloodadvances/article-pdf/4/13/3180/1810861/advancesadv2019001266.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419793 |
856 | 4 8 | u https://doi.org/10.1182/bloodadvances.2019001266 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144221407 |
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