Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer's Disease

Uddin, Md SahabSoutheast Univ, Dept Pharm, Dhaka, Bangladesh.;Pharmakon Neurosci Res Network, Dhaka, Bangladesh. (författare)

Alzheimer's disease (AD) is an irreversible chronic neurodegenerative disorder that occurs when neurons in the brain degenerate and die. Pain frequently arises in older patients with neurodegenerative diseases including AD. However, the presence of pain in older people is usually overlooked with cognitive dysfunctions. Most of the times dementia patients experience moderate to severe pain but the development of severe cognitive dysfunctions tremendously affects their capability to express the presence of pain. Currently, there are no effective treatments against AD that emphasize the necessity for increasing research to develop novel drugs for treating or preventing the disease process. Furthermore, the prospective therapeutic use of cannabinoids in AD has been studied for the past few years. In this regard, targeting the endocannabinoid system has considered as a probable therapeutic strategy to control several associated pathological pathways, such as mitochondrial dysfunction, excitotoxicity, oxidative stress, and neuroinflammation for the management of AD. In this review, we focus on recent studies about the role of cannabinoids for the treatment of pain and related neuropathological changes in AD.

Al Mamun, AbdullahSoutheast Univ, Dept Pharm, Dhaka, Bangladesh.;Pharmakon Neurosci Res Network, Dhaka, Bangladesh. (författare)
Sumsuzzman, Dewan MdSoutheast Univ, Dept Pharm, Dhaka, Bangladesh. (författare)
Ashraf, Ghulam MdKing Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia.;King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah, Saudi Arabia. (författare)
Perveen, AsmaGlocal Univ, Glocal Sch Life Sci, Saharanpur, India. (författare)
Bungau, Simona G.Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea, Romania. (författare)
Mousa, Shaker A.Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, New York, NY USA. (författare)
El-Seedi, HeshamUppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt.(Swepub:uu)heels173 (författare)
Bin-Jumah, May N.Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh, Saudi Arabia. (författare)
Abdel-Daim, Mohamed M.King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia.;Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia, Egypt. (författare)
Southeast Univ, Dept Pharm, Dhaka, Bangladesh.;Pharmakon Neurosci Res Network, Dhaka, Bangladesh.Southeast Univ, Dept Pharm, Dhaka, Bangladesh. (creator_code:org_t)

Av författaren/redakt...: Uddin, Md Sahab; Al Mamun, Abdull ...; Sumsuzzman, Dewa ...; Ashraf, Ghulam M ...; Perveen, Asma; Bungau, Simona G ...; visa fler...; Mousa, Shaker A.; El-Seedi, Hesham; Bin-Jumah, May N ...; Abdel-Daim, Moha ...; visa färre...

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