Sökning: onr:"swepub:oai:DiVA.org:uu-421550" > Association of Fact...
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000 | 17673naa a2201357 4500 | |
001 | oai:DiVA.org:uu-421550 | |
003 | SwePub | |
008 | 201015s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4215502 URI |
024 | 7 | a https://doi.org/10.1161/CIRCULATIONAHA.119.0455262 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mahmoodi, Bakhtawar K.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.;Univ Groningen, Div Hemostasis & Thrombosis, Dept Hematol, UMC Groningen, Groningen, Netherlands.4 aut |
245 | 1 0 | a Association of Factor V Leiden With Subsequent Atherothrombotic Events A GENIUS-CHD Study of Individual Participant Data |
264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2020 |
338 | a print2 rdacarrier | |
520 | a Background: Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a stronger risk factor for atherothrombotic events in patients with established CHD.Methods: We performed an individual-level meta-analysis including 25 prospective studies (18 cohorts, 3 case-cohorts, 4 randomized trials) from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) consortium involving patients with established CHD at baseline. Participating studies genotyped factor V Leiden status and shared risk estimates for the outcomes of interest using a centrally developed statistical code with harmonized definitions across studies. Cox proportional hazards regression models were used to obtain age- and sex-adjusted estimates. The obtained estimates were pooled using fixed-effect meta-analysis. The primary outcome was composite of myocardial infarction and CHD death. Secondary outcomes included any stroke, ischemic stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality.Results: The studies included 69 681 individuals of whom 3190 (4.6%) were either heterozygous or homozygous (n=47) carriers of factor V Leiden. Median follow-up per study ranged from 1.0 to 10.6 years. A total of 20 studies with 61 147 participants and 6849 events contributed to analyses of the primary outcome. Factor V Leiden was not associated with the combined outcome of myocardial infarction and CHD death (hazard ratio, 1.03 [95% CI, 0.92-1.16];I-2=28%;P-heterogeneity=0.12). Subgroup analysis according to baseline characteristics or strata of traditional cardiovascular risk factors did not show relevant differences. Similarly, risk estimates for the secondary outcomes including stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality were also close to identity.Conclusions: Factor V Leiden was not associated with increased risk of subsequent atherothrombotic events and mortality in high-risk participants with established and treated CHD. Routine assessment of factor V Leiden status is unlikely to improve atherothrombotic events risk stratification in this population. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a coronary artery disease | |
653 | a genetic association studies | |
653 | a thrombosis | |
653 | a prognosis | |
653 | a single nucleotide polymorphism | |
653 | a myocardial infarction | |
653 | a secondary prevention | |
700 | 1 | a Tragante, Viniciusu Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut |
700 | 1 | a Kleber, Marcus E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut |
700 | 1 | a Holmes, Michael V.u Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England.;Oxford Univ Hosp, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England.4 aut |
700 | 1 | a Schmidt, Amand F.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut |
700 | 1 | a McCubrey, Raymond O.u Intermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA.4 aut |
700 | 1 | a Howe, Laurence J.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut |
700 | 1 | a Direk, Kenanu UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut |
700 | 1 | a Allayee, Hoomanu Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Baranova, Ekaterina V.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.4 aut |
700 | 1 | a Braund, Peter S.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut |
700 | 1 | a Delgado, Graciela E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut |
700 | 1 | a Eriksson, Niclas,d 1978-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103 |
700 | 1 | a Gijsberts, Crystel M.u Univ Utrecht, UMC Utrecht, Lab Expt Cardiol, Utrecht, Netherlands.4 aut |
700 | 1 | a Gong, Yanu Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.4 aut |
700 | 1 | a Hartiala, Jaanau Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Inst Med Genet, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Heydarpour, Mahyaru Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA.4 aut |
700 | 1 | a Pasterkamp, Gerardu Univ Utrecht, UMC Utrecht, Dept Clin Chem, Utrecht, Netherlands.4 aut |
700 | 1 | a Kotti, Salmau UPMC, AP HP, Platform Clin Res East Paris, Dept Clin Pharmacol,URCEST,CRCEST,CRB,HUEP, Paris, France.4 aut |
700 | 1 | a Kuukasjarvi, Pekkau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiothorac Surg, Tampere, Finland.4 aut |
700 | 1 | a Lenzini, Petra A.u Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA.4 aut |
700 | 1 | a Levin, Danielu Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut |
700 | 1 | a Lyytikainen, Leo-Pekkau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Chem, Tampere, Finland.;Fimlab Labs, Dept Clin Chem, Tampere, Finland.4 aut |
700 | 1 | a Muehlschlegel, Jochen D.u Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA.4 aut |
700 | 1 | a Nelson, Christopher P.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut |
700 | 1 | a Nikus, Kjellu Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiol, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland.4 aut |
700 | 1 | a Pilbrow, Anna P.u Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.4 aut |
700 | 1 | a Wilson Tang, W. H.u Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.;Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a van der Laan, Sander W.u Univ Utrecht, UMC Utrecht, Cent Diagnost Lab, Div Labs Pharm & Biomed Genet, Utrecht, Netherlands.4 aut |
700 | 1 | a van Setten, Jessicau Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut |
700 | 1 | a Vilmundarson, Ragnar O.u Univ Ottawa, Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut |
700 | 1 | a Deanfield, Johnu UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut |
700 | 1 | a Deloukas, Panosu Queen Mary Univ London, William Harvey Res Inst, Barts & London Med Sch, London, England.;Queen Mary Univ London, Ctr Genom Hlth, London, England.4 aut |
700 | 1 | a Dudbridge, Franku Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.4 aut |
700 | 1 | a James, Stefan,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367 |
700 | 1 | a Mordi, Ify R.u Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut |
700 | 1 | a Teren, Andreju Heart Ctr Leipzig, Leipzig, Germany.;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.4 aut |
700 | 1 | a Bergmeijer, Thomas O.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.4 aut |
700 | 1 | a Body, Simon C.u Boston Univ, Sch Med, Dept Anesthesiol, Boston, MA 02118 USA.4 aut |
700 | 1 | a Bots, Michielu Univ Utrecht, UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut |
700 | 1 | a Burkhardt, Ralphu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.4 aut |
700 | 1 | a Cooper-DeHoff, Rhonda M.u Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut |
700 | 1 | a Cresci, Sharonu Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63110 USA.4 aut |
700 | 1 | a Danchin, Nicolasu Hop Europeen Georges Pompidou, AP HP, FACT French Alliance Cardiovasc Trials, Dept Cardiol, Paris, France.;Univ Paris 05, Paris, France.4 aut |
700 | 1 | a Doughty, Robert N.u Univ Auckland, Heart Hlth Res Grp, Auckland, New Zealand.4 aut |
700 | 1 | a Grobbee, Diederick E.u Univ Utrecht, UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut |
700 | 1 | a Hagström, Emilu Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)emhag677 |
700 | 1 | a Hazen, Stanley L.u Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.;Cleveland Clin, Ctr Microbiome & Human Hlth, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947 |
700 | 1 | a Hoefer, Imo E.u Univ Utrecht, UMC Utrecht, Dept Clin Chem & Hematol, Utrecht, Netherlands.4 aut |
700 | 1 | a Hovingh, G. Keesu Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.4 aut |
700 | 1 | a Johnson, Julie A.u Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut |
700 | 1 | a Kaczor, Marcin P.u Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut |
700 | 1 | a Kahonen, Mikau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Physiol, Tampere, Finland.;Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.4 aut |
700 | 1 | a Klungel, Olaf H.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.4 aut |
700 | 1 | a Laurikka, Jari O.u Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiothorac Surg, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Cardiothorac Surg, Tampere, Finland.4 aut |
700 | 1 | a Lehtimaki, Terhou Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Chem, Tampere, Finland.;Fimlab Labs, Dept Clin Chem, Tampere, Finland.4 aut |
700 | 1 | a van der Zee, Anke H.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands.4 aut |
700 | 1 | a McPherson, Ruthu Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut |
700 | 1 | a Palmer, Colin N.u Ninewells Hosp & Med Sch, Div Mol & Clin Med, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee, Scotland.4 aut |
700 | 1 | a Kraaijeveld, Adriaan O.u Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut |
700 | 1 | a Pepine, Carl J.u Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut |
700 | 1 | a Sanak, Mareku Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut |
700 | 1 | a Sattar, Naveedu Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.4 aut |
700 | 1 | a Scholz, Markusu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.4 aut |
700 | 1 | a Simon, Tabassomeu UPMC, FACT French Alliance Cardiovasc Trials, Platform Clin Res East Paris, Dept Clin Pharmacol,URCEST,CRCEST,CRB,HUEP,AP HP, Paris 06, France.;Sorbonne Univ, Paris 06, France.;Paris Sorbonne Univ, UPMC Site St Antoine, Paris, France.4 aut |
700 | 1 | a Spertus, John A.u Univ Missouri, Kansas City, MO 64110 USA.;St Lukes Mid Amer Heart Inst, Kansas City, MO USA.4 aut |
700 | 1 | a Stewart, Alexandre F. R.u Univ Ottawa, Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut |
700 | 1 | a Szczeklik, Wojciechu Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut |
700 | 1 | a Thiery, Joachimu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Hosp, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany.4 aut |
700 | 1 | a Visseren, Frank L. J.u Univ Utrecht, UMC Utrecht, Dept Vasc Med, Utrecht, Netherlands.4 aut |
700 | 1 | a Waltenberger, Johannesu Univ Munster, Dept Cardiovasc Med, Munster, Germany.4 aut |
700 | 1 | a Richards, A. Marku Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.4 aut |
700 | 1 | a Lang, Chim C.u Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut |
700 | 1 | a Cameron, Vicky A.u Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.4 aut |
700 | 1 | a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)axeak985 |
700 | 1 | a Pare, Guillaumeu McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.;Populat Hlth Res Inst, Hamilton, ON, Canada.4 aut |
700 | 1 | a Maerz, Winfriedu Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.4 aut |
700 | 1 | a Samani, Nilesh J.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut |
700 | 1 | a Hingorani, Aroon D.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut |
700 | 1 | a ten Berg, Jurrien M.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.4 aut |
700 | 1 | a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall |
700 | 1 | a Asselbergs, Folkert W.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.;UCL, Hlth Data Res UK, London, England.;UCL, Inst Hlth Informat, London, England.4 aut |
700 | 1 | a Patel, Riyaz S.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.;St Bartholomews Hosp, Barts Heart Ctr, London, England.4 aut |
710 | 2 | a St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.;Univ Groningen, Div Hemostasis & Thrombosis, Dept Hematol, UMC Groningen, Groningen, Netherlands.b Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 org |
773 | 0 | t Circulationd : Ovid Technologies (Wolters Kluwer Health)g 142:6, s. 546-555q 142:6<546-555x 0009-7322x 1524-4539 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421550 |
856 | 4 8 | u https://doi.org/10.1161/CIRCULATIONAHA.119.045526 |
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