Sökning: onr:"swepub:oai:DiVA.org:uu-421715" > Negative regulatory...
Fältnamn | Indikatorer | Metadata |
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000 | 03429naa a2200445 4500 | |
001 | oai:DiVA.org:uu-421715 | |
003 | SwePub | |
008 | 201012s2004 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4217152 URI |
024 | 7 | a https://doi.org/10.1093/intimm/dxh1792 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garaczi, Edina4 aut |
245 | 1 0 | a Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity. |
264 | c 2004-10-11 | |
264 | 1 | b Oxford University Press (OUP),c 2004 |
338 | a print2 rdacarrier | |
520 | a Histamine plays an important role in the regulation of various immunological functions. To evaluate the role of histamine in contact hypersensitivity, contact dermatitis was induced with dinitrofluorobenzene (DNFB) in histidine decarboxylase knockout (HDC-/-) histamine-deficient and wild-type mice. The DNFB-induced increase of the ear thickness was significantly higher in HDC-/- mice than in wild-type mice. Using flow cytometry, significantly lower percentages of CD4+ Th and CD8+ Tc cells, and significantly higher percentages of CD45R+ B cells were observed in the regional lymph nodes in HDC-/- mice than in wild-type mice. In the ear specimens of both groups, the majority of the infiltrating cells were neutrophils and macrophages at 24 and 48 h after challenge. Using immunohistochemistry, we observed significantly more CD45+ leukocytes in HDC-/- mice than in wild-type mice. The expression of Th1 (IL-2, IFN-gamma, TNF-alpha) and Th2 (IL-4) mRNAs was examined by quantitative real time RT-PCR in the ear samples. The levels of Th1 cytokine mRNAs both at 24 and 48 h after challenge and IL-4 mRNA at 48 h showed a significantly higher increase in HDC-/- mice than in wild-type mice. These results suggest that histamine plays a negative immunoregulatory role in DNFB-induced contact hypersensitivity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
700 | 1 | a Széll, Márta4 aut |
700 | 1 | a Jánossy, Tamás4 aut |
700 | 1 | a Koreck, Andrea4 aut |
700 | 1 | a Pivarcsi, Andor4 aut |
700 | 1 | a Buzás, Edit4 aut |
700 | 1 | a Pos, Zoltán4 aut |
700 | 1 | a Falus, András4 aut |
700 | 1 | a Dobozy, Attila4 aut |
700 | 1 | a Kemény, Lajos4 aut |
773 | 0 | t International Immunologyd : Oxford University Press (OUP)g 16:12, s. 1781-8q 16:12<1781-8x 0953-8178x 1460-2377 |
856 | 4 | u http://intimm.oxfordjournals.org/content/16/12/1781.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421715 |
856 | 4 8 | u https://doi.org/10.1093/intimm/dxh179 |
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