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Dietary cadmium exp...
Dietary cadmium exposure and chronic kidney disease : A population-based prospective cohort study of men and women
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- Thomas, Laura D. K. (författare)
- Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Elinder, Carl-Gustaf (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Akesson, Agneta (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden (creator_code:org_t)
- ELSEVIER GMBH, 2014
- 2014
- Engelska.
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Ingår i: International journal of hygiene and environmental health. - : ELSEVIER GMBH. - 1438-4639 .- 1618-131X. ; 217:7, s. 720-725
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The kidney is widely regarded as the critical organ for cadmium toxicity, however, considerable uncertainty remains regarding the clinical significance of the renal effects of cadmium at low levels of exposure. Food is the primary source of cadmium exposure in the general population with tobacco representing an important additional source. We aimed to assess the association between dietary cadmium exposure and chronic kidney disease (CKD) incidence in two large population-based, prospective cohorts of men (Cohort of Swedish Men (COSM)) and women (The Swedish Mammography Cohort (SMC)) with no history of kidney disease. At baseline 1997, men (45-79 years) and women (48-83 years), completed a self-administered questionnaire on diet and lifestyle. Dietary cadmium exposure for each individual was estimated using dietary data and concentrations of cadmium in food. During 13 years of follow-up, we ascertained 599 incident cases of CKD among men (in 481,591 person-years) and 253 cases among women (in 415,432 person-years) through linkage of the cohorts to national inpatient and outpatient registers. Hazard ratios (HR) were calculated using the Cox proportional-hazard regression model. Estimated dietary cadmium exposure was not associated with increased CKD incidence among men HR 0.97 (95% confidence interval (CI): 0.77-1.21) or women HR 0.74(95% CI: 0.53-1.04), comparing highest tertile with lowest. Our results do not support a strong association between dietary cadmium exposure and CKD at the exposure levels seen in the general population. (C) 2014 Elsevier GmbH. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Cadmium
- Chronic kidney disease
- Diet
- Prospective cohort
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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