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Body mass index and...
Body mass index and risk of non-Hodgkin's and Hodgkin's lymphoma : A meta-analysis of prospective studies
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- Larsson, Susanna C. (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2011
- 2011
- Engelska.
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Ingår i: European Journal of Cancer. - : ELSEVIER SCI LTD. - 0959-8049 .- 1879-0852. ; 47:16, s. 2422-2430
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We conducted a meta-analysis of prospective studies to summarise the epidemiologic evidence regarding the association of body mass index (BMI) with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) incidence and NHL mortality. Pertinent studies were identified by searching PubMed (1966-May 2011) and the reference lists of retrieved articles. For each study, we estimated a relative risk (RR) for a 5 kg/m(2) increase in BMI. A random-effects model was used to combine the RR estimates from individual studies. The summary RRs for a 5 kg/m(2) increase in BMI were 1.07 (95% confidence intervals (CI), 1.04-1.10) for NHL incidence (16 studies, n = 17,291 cases) and 1.14 (95% CI, 1.04-1.26) for NHL mortality (five studies, n = 3407 cases). BMI was significantly positively associated with risk of diffuse large B-cell lymphoma (RR, 1.13; 95% CI, 1.02-1.26), but not other NHL subtypes. The difference in risk estimates for subtypes was not statistically significant (P = 0.10). There was evidence of a nonlinear association between BMI and HL (P for nonlinearity = 0.01) (five studies, n = 1557 cases). The summary RRs of HL were 0.97 (95% CI, 0.85-1.12) for overweight and 1.41 (95% CI, 1.14-1.75) for obesity. These results indicate that BMI is positively associated with risk of NHL and HL as well as with NHL mortality. (C) 2011 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Body mass index
- Prospective studies
- Meta-analysis
- Lymphoma
- Obesity
- Review
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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