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Association of Leis...
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
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- Moore, Steven C. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Lee, I-Min (författare)
- Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet
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- Campbell, Peter T. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
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- Sampson, Joshua N. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Kitahara, Cari M. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Keadle, Sarah K. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Arem, Hannah (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.;USAID Bur Global Hlth, Washington, DC USA.
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- de Gonzalez, Amy Berrington (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Hartge, Patricia (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Adami, Hans-Olov (författare)
- Karolinska Institutet
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- Blair, Cindy K. (författare)
- Univ New Mexico, Div Epidemiol Biostat & Prevent Med, Albuquerque, NM 87131 USA.
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- Borch, Kristin B. (författare)
- Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway.
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- Boyd, Eric (författare)
- Information Management Serv Inc, Rockville, MD USA.
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- Check, David P. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Fournier, Agness (författare)
- Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France.
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- Freedman, Neal D. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Gunter, Marc (författare)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Int Agcy Res Canc, Sect Nutr & Metab, 150 Cours Albert Thomas, F-69372 Lyon, France.
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- Johannson, Mattias (författare)
- Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France,Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69372 Lyon, France.;Umea Univ, Dept Biobank Res, Umea, Sweden.
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- Khaw, Kay-Tee (författare)
- Univ Cambridge, Cambridge Inst Publ Hlth, Cambridge, England.
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- Linet, Martha S. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Orsini, Nicola (författare)
- Karolinska Institutet
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- Park, Yikyung (författare)
- Washington Univ, Sch Med, Div Publ Hlth Sci, St Louis, MO USA.
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- Riboli, Elio (författare)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
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- Robien, Kim (författare)
- George Washington Univ, Sch Publ Hlth, Milken Inst, Dept Exercise & Nutr Sci, Washington, DC USA.
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- Schairer, Catherine (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Sesso, Howard (författare)
- Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
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- Spriggs, Michael (författare)
- Information Management Serv Inc, Rockville, MD USA.
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- Van Dusen, Roy (författare)
- Information Management Serv Inc, Rockville, MD USA.
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Matthews, Charles E. (författare)
- NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Patel, Alpa V. (författare)
- Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
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NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. (creator_code:org_t)
- AMER MEDICAL ASSOC, 2016
- 2016
- Engelska.
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Ingår i: JAMA Internal Medicine. - : AMER MEDICAL ASSOC. - 2168-6106 .- 2168-6114. ; 176:6, s. 816-825
- Relaterad länk:
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https://jamanetwork....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- IMPORTANCE Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004). We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals for associations of leisure-time physical activity with incidence of 26 types of cancer. Leisure-time physical activity levels were modeled as cohort-specific percentiles on a continuous basis and cohort-specific results were synthesized by random-effects meta-analysis. Hazard ratios for high vs low levels of activity are based on a comparison of risk at the 90th vs 10th percentiles of activity. The data analysis was performed from January 1, 2014, to June 1, 2015. EXPOSURES Leisure-time physical activity of a moderate to vigorous intensity. MAIN OUTCOMES AND MEASURES Incident cancer during follow-up. RESULTS A total of 1.44 million participants (median [range] age, 59 [19-98] years; 57% female) and 186 932 cancers were included. High vs low levels of leisure-time physical activity were associated with lower risks of 13 cancers: esophageal adenocarcinoma (HR, 0.58; 95% CI, 0.37-0.89), liver (HR, 0.73; 95% CI, 0.55-0.98), lung (HR, 0.74; 95% CI, 0.71-0.77), kidney (HR, 0.77; 95% CI, 0.70-0.85), gastric cardia (HR, 0.78; 95% CI, 0.64-0.95), endometrial (HR, 0.79; 95% CI, 0.68-0.92), myeloid leukemia (HR, 0.80; 95% CI, 0.70-0.92), myeloma (HR, 0.83; 95% CI, 0.72-0.95), colon (HR, 0.84; 95% CI, 0.77-0.91), head and neck (HR, 0.85; 95% CI, 0.78-0.93), rectal (HR, 0.87; 95% CI, 0.80-0.95), bladder (HR, 0.87; 95% CI, 0.82-0.92), and breast (HR, 0.90; 95% CI, 0.87-0.93). Body mass index adjustment modestly attenuated associations for several cancers, but 10 of 13 inverse associations remained statistically significant after this adjustment. Leisure-time physical activity was associated with higher risks of malignant melanoma (HR, 1.27; 95% CI, 1.16-1.40) and prostate cancer (HR, 1.05; 95% CI, 1.03-1.08). Associations were generally similar between overweight/obese and normal-weight individuals. Smoking status modified the association for lung cancer but not other smoking-related cancers. CONCLUSIONS AND RELEVANCE Leisure-time physical activity was associated with lower risks of many cancer types. Health care professionals counseling inactive adults should emphasize that most of these associations were evident regardless of body size or smoking history, supporting broad generalizability of findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- Av författaren/redakt...
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Moore, Steven C.
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Lee, I-Min
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Weiderpass, Elis ...
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Campbell, Peter ...
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Sampson, Joshua ...
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Kitahara, Cari M ...
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visa fler...
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Keadle, Sarah K.
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Arem, Hannah
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de Gonzalez, Amy ...
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Hartge, Patricia
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Adami, Hans-Olov
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Blair, Cindy K.
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Borch, Kristin B ...
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Boyd, Eric
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Check, David P.
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Fournier, Agness
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Freedman, Neal D ...
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Gunter, Marc
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Johannson, Matti ...
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Khaw, Kay-Tee
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Linet, Martha S.
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Orsini, Nicola
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Park, Yikyung
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Riboli, Elio
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Robien, Kim
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Schairer, Cather ...
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Sesso, Howard
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Spriggs, Michael
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Van Dusen, Roy
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Wolk, Alicja
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Matthews, Charle ...
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Patel, Alpa V.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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JAMA Internal Me ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet