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Transglutaminase 1 ...
Transglutaminase 1 and 2 are localized in different blood cells in the freshwater crayfish Pacifastacus leniusculus
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- Junkunlo, Kingkamon (författare)
- Uppsala universitet,Jämförande fysiologi
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- Söderhäll, Kenneth (författare)
- Uppsala universitet,Jämförande fysiologi,Science for Life Laboratory, SciLifeLab
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- Söderhäll, Irene (författare)
- Uppsala universitet,Jämförande fysiologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2020
- 2020
- Engelska.
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Ingår i: Fish and Shellfish Immunology. - : ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. - 1050-4648 .- 1095-9947. ; 104, s. 83-91
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Abstract
Ämnesord
Stäng
- In the present study we show that hemocytes in the freshwater crayfish Pacifastacus leniusculus express two different transglutaminases. We describe the sequence of a previously unknown TGase (Pl_TGase1) and named this as Pl_TGase2 and compared this sequence with similar sequences from other crustaceans. The catalytic core domain is similar to the previously described TGase in P. leniusculus, but Pl_TGase2 has significant differences in the N-terminal and C-terminal domains. Further, we show conclusive evidences that these different transglutaminases are specific for different hemocyte types so that Pl_TGase1 is expressed in the hematopoietic tissue and in the cytoplasm of semigranular hemocytes, while Pl_TGase2 is expressed in vesicles in the granular hemocytes. By in situ hybridization we show that both Pl_TGase1 and Pl_TGase2 mRNA are present only in a subset of the respective hemocyte population. This observation indicates that there may be different subtypes of semigranular as well as granular hemocytes which may have different specific functions.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- Crustacean
- Hematopoiesis
- Hemocyte
- Transglutaminase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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