onr:"swepub:oai:DiVA.org:uu-423510"
Sökning: onr:"swepub:oai:DiVA.org:uu-423510" > Season of birth, ch...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Almqvist, CatarinaKarolinska Institutet (författare)
Season of birth, childhood asthma and allergy in a nationwide cohort : Mediation through lower respiratory infections
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
- 2019-12-28
- Stockholm :Wiley,2020
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-423510
- ISSN:0954-7894
- 10616/48470hdl
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423510URI
- https://doi.org/10.1111/cea.13542DOI
- http://hdl.handle.net/10616/48470URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142527884URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- BackgroundPrevious studies have suggested an association between season of birth and risk of childhood asthma and allergic disease. The association may be modified by birth year and region, or mediated by respiratory tract infections.ObjectiveWe aimed to estimate the association between season of birth and risk of childhood asthma/wheeze or allergic rhinoconjunctivitis in a population‐based setting, and the mediating effect of lower respiratory infections.MethodsTwo population‐based cohorts were identified from the nationwide Swedish Medical Birth, Patient and Prescribed Drug Registers. The association between birth month/season and asthma/wheeze incidence was analysed using Cox proportional regression in the younger cohort born 2005‐2010 (n = 582 494) and asthma/allergic rhinoconjunctivitis prevalence during the 7th year of life using log‐binomial models in the older cohort born 2001‐2004 (n = 367 583). Interactions were formally tested. Mediation analyses to address the effect of lower respiratory infections were performed in the older cohort using the R package “medflex.”ResultsChildren born during fall and winter had an increased risk of asthma/wheeze after 2 years of age in the younger cohort: hazard ratio 1.24 (95% confidence interval, CI 1.17, 1.33) for winter and risk of prevalent asthma during their 7th year of life in the older cohort; prevalence ratio (PR) 1.12 (95% CI 1.08, 1.16) for winter. These estimates were partly mediated by lower respiratory infections; the indirect effect for winter compared with summer was PR 1.03 (95% CI 1.03, 1.04). The association was similar for allergic rhinoconjunctivitis in the 7th year of life, but not mediated by respiratory infections.ConclusionWe found that the association between season of birth and risk of childhood asthma/wheeze, but not allergic rhinoconjunctivitis, is partly mediated through lower respiratory infections.Clinical relevanceThis has important implications for patient care, such as asthma management programmes to notify timing of seasonality for viral respiratory tract infections.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- allergy
- asthma
- epidemiology
- pollen
- register
- respiratory infectious disease
- season
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ekberg, SaraKarolinska Institutet (författare)
- Rhedin, SamuelKarolinska Institutet (författare)
- Fang, FangKarolinska Institutet (författare)
- Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)tovfa878 (författare)
- Lundholm, CeciliaKarolinska Institutet (författare)
- Karolinska InstitutetScience for Life Laboratory, SciLifeLab (creator_code:org_t)
- Karolinska Institutet
- Karolinska Institutet
Sammanhörande titlar
- Ingår i:Clinical and Experimental AllergyStockholm : Wiley50:2, s. 222-2300954-78941365-2222
Internetlänk
Hitta via bibliotek
- Clinical and Experimental Allergy (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Almqvist, Catari ...
- Ekberg, Sara
- Rhedin, Samuel
- Fang, Fang
- Fall, Tove, 1979 ...
- Lundholm, Cecili ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Lungmedicin och ...
- Artiklar i publikationen
- Clinical and Exp ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
