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Clinical outcomes o...
Clinical outcomes of patients with diabetes and atrial fibrillation treated with apixaban : results from the ARISTOTLE trial
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- Ezekowitz, Justin A. (författare)
- Univ Alberta, Edmonton, AB, Canada.
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- Lewis, Basil S. (författare)
- Lady Davis Carmel Med Ctr, Haifa, Israel.;Technion IIT, Ruth & Bruce Rappaport Sch Med, Haifa, Israel.
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- Lopes, Renato D. (författare)
- Duke Med, Duke Clin Res Inst, Durham, NC USA.
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Wojdyla, Daniel M. (författare)
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- McMurray, John J. V. (författare)
- Western Infirm & Associated Hosp, Glasgow, Lanark, Scotland.
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- Hanna, Michael (författare)
- Bristol Myers Squibb, Princeton, NJ USA.
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- Atar, Dan (författare)
- Oslo Univ Hosp, Oslo, Norway.
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- Bahit, M. Cecilia (författare)
- INECO, Neurociencias Orono, Rosario, Santa Fe, Argentina.
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- Keltai, Matyas (författare)
- Semmelweis Univ, Hungarian Inst Cardiol, Budapest, Hungary.
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- Lopez-Sendon, Jose L. (författare)
- Hosp Univ La Paz, Madrid, Spain.
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- Pais, Prem (författare)
- St Johns Med Coll, Bangalore, Karnataka, India.
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- Ruzyllo, Witold (författare)
- Natl Inst Cardiol, Warsaw, Poland.
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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Granger, Christopher B. (författare)
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Alexander, John H. (författare)
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Univ Alberta, Edmonton, AB, Canada Lady Davis Carmel Med Ctr, Haifa, Israel.;Technion IIT, Ruth & Bruce Rappaport Sch Med, Haifa, Israel. (creator_code:org_t)
- 2015-03-20
- 2015
- Engelska.
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Ingår i: European Heart Journal - Cardiovascular Pharmacotherapy. - : OXFORD UNIV PRESS. - 2055-6837 .- 2055-6845. ; 1:2, s. 86-94
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims We compared clinical outcomes in patients with AF with and without diabetes in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Methods and results The main efficacy endpoints were SSE and mortality; safety endpoints were major and major/clinically relevant non-major bleeding. A total of 4547/18 201 (24.9%) patients had diabetes who were younger (69 vs. 70 years), more had coronary artery disease (39 vs. 31%), and higher mean CHADS(2) (2.9 vs. 1.9) and HAS-BLEDscores (1.9 vs. 1.7) (all P, 0.0001) than patients without diabetes. Patients with diabetes receiving apixaban had lower rates of SSE [hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.53-1.05), all-cause mortality (HR 0.83, 95% CI 0.67-1.02), cardiovascular mortality (HR 0.89, 95% CI 0.66-1.20), intra-cranial haemorrhage (HR 0.49, 95% CI 0.25-0.95), and a similar rate of myocardial infarction (HR 1.02, 95% CI 0.62-1.67) compared with warfarin. For major bleeding, a quantitative interaction was seen (P-interaction = 0.003) with a greater reduction in major bleeding in patients without diabetes even after multivariable adjustment. Other measures of bleeding showed a consistent reduction with apixaban compared with warfarin without a significant interaction based on diabetes status. Conclusion Apixaban has similar benefits on reducing stroke, decreasing mortality, and causing less intra-cranial bleeding than warfarin in patients with and without diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Diabetes
- Atrial fibrillation
- Clinical outcomes
- Oral anti-coagulant
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Till lärosätets databas
- Av författaren/redakt...
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Ezekowitz, Justi ...
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Lewis, Basil S.
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Lopes, Renato D.
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Wojdyla, Daniel ...
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McMurray, John J ...
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Hanna, Michael
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Atar, Dan
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Bahit, M. Cecili ...
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Keltai, Matyas
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Lopez-Sendon, Jo ...
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Pais, Prem
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Ruzyllo, Witold
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Wallentin, Lars, ...
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Granger, Christo ...
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Alexander, John ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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European Heart J ...
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Uppsala universitet