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Prognostic implicat...
Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy
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- Menter, Thomas (författare)
- Univ Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
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- Tzankov, Alexandar (författare)
- Univ Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
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- Zucca, Emanuele (författare)
- Oncol Inst Southern Switzerland, Div Med Oncol, Bellinzona, Switzerland.;Inst Oncol Res, Bellinzona, Switzerland.;Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland.
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- Kimby, Eva (författare)
- Karolinska Institutet
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- Hultdin, Magnus (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.
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- Sundström, Christer (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Rose-Marie Amini
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- Beiske, Klaus (författare)
- Oslo Univ Hosp, Dept Pathol, Oslo, Norway.;Univ Oslo, Med Fac, Inst Clin Med, Oslo, Norway.
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- Cogliatti, Sergio (författare)
- Cantonal Hosp, Inst Pathol, St Gallen, Switzerland.
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- Banz, Yara (författare)
- Univ Bern, Inst Pathol, Bern, Switzerland.
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- Cathomas, Gieri (författare)
- Kantonsspital Baselland, Inst Pathol, Liestal, Switzerland.
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- Katjalainen-Lindsberg, Marja-Liisa (författare)
- Helsinki Univ Hosp, HUSLAB, Helsinki, Finland.
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- Grobholz, Rainer (författare)
- Cantonal Hosp Aarau, Inst Pathol, Aarau, Switzerland.
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- Mazzucchelli, Luca (författare)
- Inst Pathol, Locarno, Switzerland.
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- Sander, Birgitta (författare)
- Karolinska Institutet
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- Hawle, Hanne (författare)
- SAKK Coordinating Ctr, Bern, Switzerland.
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- Hayoz, Stefanie (författare)
- SAKK Coordinating Ctr, Bern, Switzerland.
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- Dirnhofer, Stefan (författare)
- Univ Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
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Univ Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland Oncol Inst Southern Switzerland, Div Med Oncol, Bellinzona, Switzerland.;Inst Oncol Res, Bellinzona, Switzerland.;Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland. (creator_code:org_t)
- 2020-02-03
- 2020
- Engelska.
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Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 189:4, s. 707-717
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microenvironment of a clinically well-characterized prospective cohort (study SAKK35/10, NCT00544219) of 154 treatment-naive FL patients in need of therapy, who have been treated with rituximab only or a combination of rituximab and the immunomodulatory drug lenalidomide/Revlimid (R) A high ratio of CD4- to CD8-positive T cells (P = 0 center dot 009) and increased amounts of PD1(+) tumour-infiltrating T cells (P = 0 center dot 007) were associated with inferior progression-free survival in the whole cohort. Interestingly, the prognostic impact of PD1(+) T cells and the CD4/CD8 ratio lost its significance in the subgroup treated with R-2. In the latter group, high amounts of GATA3(+) T helper (Th2) equivalents were associated with better progression-free survival (P < 0 center dot 001). We identified tumour microenvironmental features that allow prognostic stratification with respect to immuno- and combined immuno- and immunomodulatory therapy. Our analysis indicates that lenalidomide may compensate the adverse prognostic implication of higher amounts of CD4(+) and, particularly, PD1(+) T cells and that it has favourable effects mainly in cases with higher amounts of Th2 equivalents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- follicular lymphoma
- lenalidomide
- rituximab
- PD1
- GATA3
- Patologi
- Pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Menter, Thomas
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Tzankov, Alexand ...
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Zucca, Emanuele
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Kimby, Eva
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Hultdin, Magnus
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Sundström, Chris ...
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visa fler...
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Beiske, Klaus
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Cogliatti, Sergi ...
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Banz, Yara
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Cathomas, Gieri
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Katjalainen-Lind ...
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Grobholz, Rainer
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Mazzucchelli, Lu ...
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Sander, Birgitta
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Hawle, Hanne
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Hayoz, Stefanie
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Dirnhofer, Stefa ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
- Artiklar i publikationen
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British Journal ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet