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Fungal oxylipins di...
Fungal oxylipins direct programmed developmental switches in filamentous fungi
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- Niu, Mengyao (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Steffan, Breanne N. (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Fischer, Gregory J. (författare)
- Univ Wisconsin, Dept Genet, Madison, WI 53706 USA.
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- Venkatesh, Nandhitha (författare)
- Univ Wisconsin, Dept Plant Pathol, Madison, WI 53706 USA.
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- Raffa, Nicholas L. (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Wettstein, Molly A. (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Bok, Jin Woo (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Greco, Claudio (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.
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- Zhao, Can (författare)
- Univ Manchester, Div Infect Immun & Resp Med, Manchester Fungal Infect Grp, Manchester, Lancs, England.
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- Berthier, Erwin (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.;Univ Wisconsin, Dept Biomed Engn, Madison, WI USA.
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- Oliw, E, 1948- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Beebe, David (författare)
- Univ Wisconsin, Dept Biomed Engn, Madison, WI USA.;Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA.
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- Bromley, Michael (författare)
- Univ Manchester, Div Infect Immun & Resp Med, Manchester Fungal Infect Grp, Manchester, Lancs, England.
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- Keller, Nancy P. (författare)
- Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA.;Univ Wisconsin Madison, Dept Bacteriol, Madison, WI 53706 USA.
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Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA Univ Wisconsin, Dept Genet, Madison, WI 53706 USA. (creator_code:org_t)
- 2020-10-14
- 2020
- Engelska.
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Ingår i: Nature Communications. - : NATURE RESEARCH. - 2041-1723. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Filamentous fungi differentiate along complex developmental programs directed by abiotic and biotic signals. Currently, intrinsic signals that govern fungal development remain largely unknown. Here we show that an endogenously produced and secreted fungal oxylipin, 5,8-diHODE, induces fungal cellular differentiation, including lateral branching in pathogenic Aspergillus fumigatus and Aspergillus flavus, and appressorium formation in the rice blast pathogen Magnaporthe grisea. The Aspergillus branching response is specific to a subset of oxylipins and is signaled through G-protein coupled receptors. RNA-Seq profiling shows differential expression of many transcription factors in response to 5,8-diHODE. Screening of null mutants of 33 of those transcription factors identifies three transcriptional regulators that appear to mediate the Aspergillus branching response; one of the mutants is locked in a hypo-branching phenotype, while the other two mutants display a hyper-branching phenotype. Our work reveals an endogenous signal that triggers crucial developmental processes in filamentous fungi, and opens new avenues for research on the morphogenesis of filamentous fungi.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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Niu, Mengyao
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Steffan, Breanne ...
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Fischer, Gregory ...
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Venkatesh, Nandh ...
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Raffa, Nicholas ...
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Wettstein, Molly ...
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visa fler...
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Bok, Jin Woo
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Greco, Claudio
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Zhao, Can
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Berthier, Erwin
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Oliw, E, 1948-
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Beebe, David
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Bromley, Michael
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Keller, Nancy P.
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visa färre...
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- NATURVETENSKAP
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Uppsala universitet