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  • Augustijns, PatrickKatholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium. (författare)

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique : History, methodology and applications

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • ELSEVIER,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-425492
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425492URI
  • https://doi.org/10.1016/j.ejps.2020.105517DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption after drug product administration to healthy subjects. In the last twenty years, collaborative initiatives have led to a plethora of clinical aspiration studies that aimed to unravel the luminal drug behavior of an orally administered drug product. The obtained drug concentration-time profiles from different segments in the GI tract were a valuable source of information to optimize and/or validate predictive in vitro and in silico tools, frequently applied in the non-clinical stage of drug product development. Sampling techniques are presently not only being considered as a stand-alone technique but are also used in combination with other in vivo techniques (e.g., gastric motility recording, magnetic resonance imaging (MRI)). By doing so, various physiological variables can be mapped simultaneously and evaluated for their impact on luminal drug and formulation behavior. This comprehensive review aims to describe the history, challenges and opportunities of the aspiration technique with a specific focus on how this technique can unravel the luminal behavior of drug products inside the human GI tract by providing a summary of studies performed over the last 20 years. A section `Best practices' on how to perform the studies and how to treat the aspirated samples is described. In the conclusion, we focus on future perspectives concerning this technique.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vertzoni, MariaNatl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece. (författare)
  • Reppas, ChristosNatl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece. (författare)
  • Langguth, PeterJohannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, D-55131 Mainz, Germany. (författare)
  • Lennernäs, HansUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)hanslenn (författare)
  • Abrahamsson, BertilAstraZeneca Gothenburg, Operat, Oral Prod Dev Pharmaceut Technol & Dev, S-43183 Molndal, Sweden. (författare)
  • Hasler, William L.Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA. (författare)
  • Baker, Jason R.Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA. (författare)
  • Vanuytsel, TimKatholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium. (författare)
  • Tack, JanKatholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium. (författare)
  • Corsetti, MauraNottingham Univ Hosp NHS Trust, NIHR Nottingham Biomed Res Ctr BRC, Nottingham, England.;Univ Nottingham, Nottingham, England.;Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Nottingham, England. (författare)
  • Bermejo, MarivalMiguel Hernandez Univ, Dept Engn Pharm Sect, Alicante 03550, Spain. (författare)
  • Paixao, PauloUniv Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal. (författare)
  • Amidon, Gordon L.Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA. (författare)
  • Hens, BartKatholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium. (författare)
  • Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Pharmaceutical Sciences: ELSEVIER1550928-09871879-0720

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