Sökning: onr:"swepub:oai:DiVA.org:uu-425614" >
Metabolic regulatio...
Metabolic regulation of calcium signaling in beta cells
-
- Idevall Hagren, Olof, 1980- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Tengholm, Anders, 1971- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
(creator_code:org_t)
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2020
- 2020
- Engelska.
-
Ingår i: Seminars in Cell and Developmental Biology. - : ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. - 1084-9521 .- 1096-3634. ; 103, s. 20-30
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The cytoplasmic Ca2+ concentration ([Ca2+](cyt)) regulates a vast number of cellular functions, including insulin secretion from beta cells. The major physiological insulin secretagogue, glucose, triggers [Ca2+](cyt) oscillations in beta cells. Synchronization of the oscillations among the beta cells within an islet underlies the generation of pulsatile insulin secretion. This review describes the mechanisms generating [Ca2+](cyt) oscillations, the interactions between [Ca2+](cyt) and cell metabolism, as well as the contribution of various organelles to the shaping of [Ca2+](cyt) signals and insulin secretion. It also discusses how Ca2+ signals are coordinated and spread throughout the islets and data indicating that altered Ca2+ signaling is associated with beta cell dysfunction and development of type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Ca2
- Oscillations
- Islets
- Endoplasmic reticulum
- Mitochondria
- Secretory granules
- Acidic stores
- Microdomains
- Insulin secretion
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas