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Assessing the Benef...
Assessing the Beneficial Effects of the Immunomodulatory Glycan LNFPIII on Gut Microbiota and Health in a Mouse Model of Gulf War Illness
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- Mote, Ryan S. (författare)
- Univ Georgia, Dept Physiol & Pharmacol, Athens, GA 30602 USA
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- Carpenter, Jessica M. (författare)
- Univ Georgia, Dept Physiol & Pharmacol, Athens, GA 30602 USA
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- Dockman, Rachel L. (författare)
- Univ Georgia, Dept Physiol & Pharmacol, Athens, GA 30602 USA
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- Steinberger, Andrew J. (författare)
- Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA
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- Suen, Garret (författare)
- Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA
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- Norberg, Thomas, 1948- (författare)
- Uppsala universitet,Organisk kemi
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- Harn, Donald A. (författare)
- Univ Georgia, Dept Infect Dis, Athens, GA 30602 USA; Univ Georgia, Ctr Trop & Emerging Infect Dis, Athens, GA 30602 USA
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- Wagner, John J. (författare)
- Univ Georgia, Dept Physiol & Pharmacol, Athens, GA 30602 USA
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- Filipov, Nikolay M. (författare)
- Univ Georgia, Dept Physiol & Pharmacol, Athens, GA 30602 USA
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(creator_code:org_t)
- 2020-09-27
- 2020
- Engelska.
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 17:19
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The microbiota’s influence on host (patho) physiology has gained interest in the context of Gulf War Illness (GWI), a chronic disorder featuring dysregulation of the gut–brain–immune axis. This study examined short- and long-term effects of GWI-related chemicals on gut health and fecal microbiota and the potential benefits of Lacto-N-fucopentaose-III (LNFPIII) treatment in a GWI model. Male C57BL/6J mice were administered pyridostigmine bromide (PB; 0.7 mg/kg) and permethrin (PM; 200 mg/kg) for 10 days with concurrent LNFPIII treatment (35 μg/mouse) in a short-term study (12 days total) and delayed LNFPIII treatment (2×/week) beginning 4 months after 10 days of PB/PM exposure in a long-term study (9 months total). Fecal 16S rRNA sequencing was performed on all samples post-LNFPIII treatment to assess microbiota effects of GWI chemicals and acute/delayed LNFPIII administration. Although PB/PM did not affect species composition on a global scale, it affected specific taxa in both short- and long-term settings. PB/PM elicited more prominent long-term effects, notably, on the abundances of bacteria belonging to Lachnospiraceae and Ruminococcaceae families and the genus Allobaculum. LNFPIII improved a marker of gut health (i.e., decreased lipocalin-2) independent of GWI and, importantly, increased butyrate producers (e.g., Butyricoccus, Ruminococcous) in PB/PM-treated mice, indicating a positive selection pressure for these bacteria. Multiple operational taxonomic units correlated with aberrant behavior and lipocalin-2 in PB/PM samples; LNFPIII was modulatory. Overall, significant and lasting GWI effects occurred on specific microbiota and LNFPIII treatment was beneficial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Gulf War Illness
- gut inflammation and health
- gut microbiome
- lacto-N-fucopentaose-III (LNFPIII)
- permethrin
- pyridostigmine bromide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mote, Ryan S.
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Carpenter, Jessi ...
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Dockman, Rachel ...
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Steinberger, And ...
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Suen, Garret
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Norberg, Thomas, ...
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Harn, Donald A.
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Wagner, John J.
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Filipov, Nikolay ...
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