Sökning: onr:"swepub:oai:DiVA.org:uu-430293" >
Cost-effectiveness ...
Cost-effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab in patients with a history of myocardial infarction in Sweden
-
Landmesser, Ulf (författare)
-
- Lindgren, Peter (författare)
- Karolinska Institutet
-
- Hagström, Emil (författare)
- Uppsala universitet,Kardiologi
-
visa fler...
-
van Hout, Ben (författare)
-
Villa, Guillermo (författare)
-
Pemberton-Ross, Peter (författare)
-
Arellano, Jorge (författare)
-
- Svensson, Maria K. (författare)
- Uppsala universitet,Njurmedicin,Medical Affairs, Amgen AB, Gustav III: s Boulevard 54, 169 74, Solna, Sweden.
-
Sibartie, Mahendra (författare)
-
Fonarow, Gregg C (författare)
-
Svensson, ME (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-10-16
- 2022
- Engelska.
-
Ingår i: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press (OUP). - 2058-5225 .- 2058-1742. ; 8:1, s. 31-38
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: To assess the cost-effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab added to standard-of-care lipid-lowering treatment [maximum tolerated dose (MTD) of statin and ezetimibe] in Swedish patients with a history of myocardial infarction (MI).Methods and results: Cost-effectiveness was evaluated using a Markov model based on Swedish observational data on cardiovascular event rates and efficacy from the FOURIER trial. Three risk profiles were considered: recent MI in the previous year; history of MI with a risk factor; and history of MI with a second event within 2 years. For each population, three minimum baseline low-density lipoprotein cholesterol (LDL-C) levels were considered: 2.5 mmol/L (≈100 mg/dL), based on the current reimbursement recommendation in Sweden; 1.8 mmol/L (≈70 mg/dL), based on 2016 ESC/EAS guidelines; and 1.4 mmol/L (≈55 mg/dL), or 1.0 mmol/L (≈40 mg/dL) for MI with a second event, based on 2019 ESC/EAS guidelines. Proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab was associated with increased quality-adjusted life-years and costs vs. standard-of-care therapy. Incremental cost-effectiveness ratios (ICERs) were below SEK700 000 (∼€66 500), the generally accepted willingness-to-pay threshold in Sweden, for minimum LDL-C levels of 2.3 (recent MI), 1.7 (MI with a risk factor), and 1.7 mmol/L (MI with a second event). Sensitivity analyses demonstrated that base-case results were robust to changes in model parameters.Conclusion: Proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab added to MTD of statin and ezetimibe may be considered cost-effective at its list price for minimum LDL-C levels of 1.7–2.3 mmol/L, depending on risk profile, with ICERs below the accepted willingness-to-pay threshold in Sweden.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cost-effectiveness
- Evolocumab
- Low-density lipoprotein cholesterol
- Myocardial infarction
- PCSK9 inhibitors
- Statins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Landmesser, Ulf
-
Lindgren, Peter
-
Hagström, Emil
-
van Hout, Ben
-
Villa, Guillermo
-
Pemberton-Ross, ...
-
visa fler...
-
Arellano, Jorge
-
Svensson, Maria ...
-
Sibartie, Mahend ...
-
Fonarow, Gregg C
-
Svensson, ME
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
European Heart J ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet