Sökning: onr:"swepub:oai:DiVA.org:uu-430329" > Serial measurement ...
Fältnamn | Indikatorer | Metadata |
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000 | 04706naa a2200553 4500 | |
001 | oai:DiVA.org:uu-430329 | |
003 | SwePub | |
008 | 210108s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4303292 URI |
024 | 7 | a https://doi.org/10.1111/jth.149472 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aulin, Juliau Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)julau101 |
245 | 1 0 | a Serial measurement of interleukin-6 and risk of mortality in anticoagulated patients with atrial fibrillation :b Insights from ARISTOTLE and RE-LY trials. |
264 | 1 | b Elsevier BV,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: The inflammatory biomarker interleukin-6 (IL-6) is associated with mortality in atrial fibrillation (AF).OBJECTIVE: To investigate if repeated IL-6 measurements improve the prognostication for stroke or systemic embolism, major bleeding, and mortality in anticoagulated patients with AF.METHODS: IL-6 levels by ELISA were measured at study entry and at 2 months in 4830 patients in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial with 1.8 years median follow-up. In the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial, IL-6 was measured at study entry, 3, 6, and 12 months in 2559 patients with 2.0 years median follow-up. Associations between a second IL-6 measurement and outcomes, adjusted for baseline IL-6, clinical variables, and other cardiovascular biomarkers, were analyzed by Cox regression.RESULTS: Median IL-6 levels were 2.0 ng/L (interquartile range [IQR] 1.30-3.20) and 2.10 ng/L (IQR 1.40-3.40) at the two time-points in ARISTOTLE, and, in RE-LY, 2.5 ng/L (IQR 1.6-4.3), 2.5 ng/L (IQR 1.6-4.2), 2.4 ng/L (IQR 1.6, 3.9), and 2.4 ng/L (IQR 1.5, 3.9), respectively. IL-6 was associated with mortality; hazard ratios per 50% higher IL-6 at 2 or 3 months, respectively, were 1.32 (95% confidence interval, 1.23-1.41; P < .0001) in ARISTOTLE, and 1.11 (1.01-1.22, P = .0290) in RE-LY; with improved C index from 0.74 to 0.76 in ARISTOTLE, but not in the smaller RE-LY cohort. There were no consistent associations with second IL-6 and stroke or systemic embolism, or major bleeding.CONCLUSIONS: Persistent systemic inflammatory activity, assessed by repeated IL-6 measurements, is associated with mortality independent of established clinical risk factors and other strong cardiovascular biomarkers in anticoagulated patients with AF. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a anticoagulants | |
653 | a atrial fibrillation | |
653 | a inflammation | |
653 | a interleukin-6 | |
653 | a mortality | |
653 | a stroke | |
700 | 1 | a Hijazi, Ziadu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)ziahi940 |
700 | 1 | a Siegbahn, Agneta,d 1947-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi,UCR4 aut0 (Swepub:uu)agsie424 |
700 | 1 | a Andersson, Ulrikau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)ulran224 |
700 | 1 | a Alexander, John H4 aut |
700 | 1 | a Connolly, Stuart J4 aut |
700 | 1 | a Ezekowitz, Michael D4 aut |
700 | 1 | a Gersh, Bernard J4 aut |
700 | 1 | a Granger, Christopher B4 aut |
700 | 1 | a Horowitz, John4 aut |
700 | 1 | a Hylek, Elaine M4 aut |
700 | 1 | a Lopes, Renato D4 aut |
700 | 1 | a Yusuf, Salim4 aut |
700 | 1 | a Wallentin, Lars,d 1943-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),UCR4 aut0 (Swepub:uu)larswall |
700 | 1 | a Oldgren, Jonas,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)jonaoldg |
710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t Journal of Thrombosis and Haemostasisd : Elsevier BVg 18:9, s. 2287-2295q 18:9<2287-2295x 1538-7933x 1538-7836 |
856 | 4 | u https://doi.org/10.1111/jth.14947y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1515351/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jth.14947 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430329 |
856 | 4 8 | u https://doi.org/10.1111/jth.14947 |
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