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Incidence of oncoge...
Incidence of oncogenic HPV and HPV-related dysplasia five years after a negative HPV test by self-sampling in elderly women
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- Hermansson, Ruth S. (författare)
- Örebro universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Olovsson, Matts, 1958- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Gustavsson, Inger M. (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden
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- Gyllensten, Ulf B. (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden
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- Lindkvist, Olga (författare)
- Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Hedlund Lindberg, Julia (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden
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- Lillsunde-Larsson, Gabriella, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine
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- Lindström, Annika K, 1953- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2022-08-03
- 2022
- Engelska.
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Ingår i: Infectious Agents and Cancer. - : Springer Nature. - 1750-9378. ; 17:42
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: Cervical cancer prevention for older women can be challenging since there are no specific guidelines for this group. This study aimed to determine the incidence of oncogenic HPV and HPV-related dysplasia in elderly women 5 years after being HPV negative.Methods: Invited women participated five years earlier in a study where self-sampling for HPV testing was applied, at this time, they were all HPV negative. The women were now, five years later invited to perform self-sampling for HPV testing. Women with a positive result performed a repeat HPV test. Those with a positive repeat HPV test were examined by colposcopy, biopsy and cytology.Results: Of the 804 invited women, 634 (76.9%) agreed to participate in the study and a self-sampling kit was sent to them. Of these, 99.6% (632/634) sent a sample to the HPV laboratory. The participation rate in each age group was 93.3% at age 65, 74.0% at age 70, 80.7% at age 75 and 64.6% at age 80. Overall 18 women (2.8%, 95% CI 3.2 to 6.0) were HPV positive in the first test and 8 (1.3%, 95% CI 0.6 to 2.6) in the second test. Sampling for the second test was done on average 5.4 months after the first test. Fifty per cent (4/8) of the women with a positive repeat test had dysplasia in histology.Conclusions: The incidence of HPV in previously HPV-negative elderly women was low. Among women who were HPV positive in a repeat test, there was a high prevalence of low grade dysplasia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cervix
- HPV
- cervical intraepithelial neoplasia
- elderly
- incidence
- self-sampling
- Hälso- och sjukvårdsforskning
- Health Care Research
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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