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Antiplasmodial and ...
Antiplasmodial and antileishmanial flavonoids from Mundulea sericea
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- Chepkirui, Carolyne (författare)
- University of Nairobi
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- Ochieng, Purity J (författare)
- University of Nairobi
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- Sarkar, Biswajyoti (författare)
- West Bengal State University
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- Hussain, Aabid (författare)
- West Bengal State University
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- Pal, Chiranjib (författare)
- West Bengal State University
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- Yang, Li Jun (författare)
- Macau University of Science and Technology
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- Coghi, Paolo (författare)
- Macau University of Science and Technology
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- Akala, Hoseah M (författare)
- Kenya Medical Research Institute
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- Derese, Solomon (författare)
- University of Nairobi
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- Ndakala, Albert (författare)
- University of Nairobi
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- Heydenreich, Matthias (författare)
- Universität Potsdam
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- Wong, Vincent K W (författare)
- Macau University of Science and Technology
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- Erdélyi, Máté, 1975- (författare)
- Uppsala universitet,Organisk kemi
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- Yenesew, Abiy (författare)
- University of Nairobi
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Fitoterapia (Milano). - : Elsevier BV. - 0367-326X .- 1873-6971. ; 149
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 μM) and HePG2 (IC50 10.8 μM) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 μM) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Chemistry with specialization in Organic Chemistry
- Kemi med inriktning mot organisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chepkirui, Carol ...
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Ochieng, Purity ...
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Sarkar, Biswajyo ...
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Hussain, Aabid
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Pal, Chiranjib
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Yang, Li Jun
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visa fler...
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Coghi, Paolo
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Akala, Hoseah M
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Derese, Solomon
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Ndakala, Albert
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Heydenreich, Mat ...
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Wong, Vincent K ...
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Erdélyi, Máté, 1 ...
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Yenesew, Abiy
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Organisk kemi
- Artiklar i publikationen
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Fitoterapia (Mil ...
- Av lärosätet
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Uppsala universitet