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Sökning: onr:"swepub:oai:DiVA.org:uu-435884" > The effects of preo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004452naa a2200565 4500
001oai:DiVA.org:uu-435884
003SwePub
008210301s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4358842 URI
0247 a https://doi.org/10.1097/EJA.00000000000014122 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bulte, Carolien S. E.4 aut
2451 0a The effects of preoperative moderate to severe anaemia on length of hospital stay :b A propensity score-matched analysis in non-cardiac surgery patients
264 1b Wolters Kluwer,c 2021
338 a print2 rdacarrier
520 a BACKGROUND Anaemia is frequently recorded during preoperative screening and has been suggested to affect outcomes after surgery negatively.OBJECTIVES The objectives were to assess the frequency of moderate to severe anaemia and its association with length of hospital stay.DESIGN Post hoc analysis of the international observational prospective ‘Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study.PATIENTS AND SETTING The current analysis included adult patients requiring general anaesthesia for non-cardiac surgery. Preoperative anaemia was defined as a haemoglobin concentration of 11 g dl−1 or lower, thus including moderate and severe anaemia according to World Health Organisation criteria.MAIN OUTCOME MEASURES The primary outcome was length of hospital stay. Secondary outcomes included hospital mortality, intra-operative adverse events and postoperative pulmonary complications (PPCs).RESULTS Haemoglobin concentrations were available for 8264 of 9864 patients. Preoperative moderate to severe anaemia was present in 7.7% of patients. Multivariable analysis showed that preoperative moderate to severe anaemia was associated with an increased length of hospital stay with a mean difference of 1.3 ((95% CI 0.8 to 1.8) days; P < .001). In the propensity-matched analysis, this association remained present, median 4.0 [IQR 1.0 to 5.0] vs. 2.0 [IQR 0.0 to 5.0] days, P = .001. Multivariable analysis showed an increased in-hospital mortality (OR 2.9 (95% CI 1.1 to 7.5); P = .029), and higher incidences of intra-operative hypotension (36.3 vs. 25.3%; P < .001) and PPCs (17.1 vs. 10.5%; P = .001) in moderately to severely anaemic patients. However, this was not confirmed in the propensity score-matched analysis.CONCLUSIONS In this international cohort of non-cardiac surgical patients, preoperative moderate to severe anaemia was associated with a longer duration of hospital stay but not increased intra-operative complications, PPCs or in-hospital mortality.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Physiology
653 a Fysiologi
653 a Anaesthesiology and Intensive Care
653 a Anestesiologi och intensivvård
7001 a Boer, Christa4 aut
7001 a Hemmes, Sabrine N. T.4 aut
7001 a Serpa Neto, Ary4 aut
7001 a Binnekade, Jan M.4 aut
7001 a Hedenstierna, Göran,d 1941-u Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)goranhed
7001 a Jaber, Samir4 aut
7001 a Hiesmayr, Michael4 aut
7001 a Hollmann, Markus W.4 aut
7001 a Mills, Gary H.4 aut
7001 a Vidal Melo, Marcos F.4 aut
7001 a Pearse, Rupert M.4 aut
7001 a Putensen, Christian4 aut
7001 a Schmid, Werner4 aut
7001 a Severgnini, Paolo4 aut
7001 a Wrigge, Hermann4 aut
7001 a Gama de Abreu, Marcelo4 aut
7001 a Pelosi, Paolo4 aut
7001 a Schultz, Marcus J.4 aut
7102 a Uppsala universitetb Hedenstiernalaboratoriet4 org
7730 t European Journal of Anaesthesiologyd : Wolters Kluwerg 38:6, s. 571-581q 38:6<571-581x 0265-0215x 1365-2346
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435884
8564 8u https://doi.org/10.1097/EJA.0000000000001412

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