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Tonic GABA-activate...
Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
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- Netsyk, Olga (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Hammoud, Hayma (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Korol, Sergiy (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Jin, Zhe (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Tafreshiha, Atieh (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Birnir, Bryndis (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 2020-06-13
- 2020
- Engelska.
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Ingår i: Hippocampus. - UK : John Wiley & Sons. - 1050-9631 .- 1098-1063. ; 30:11, s. 1146-1157
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The hippocampus is a medial temporal lobe structure in the brain and is widely studied for its role in memory and learning, in particular, spacial memory and emotional responses. It was thought to be a homogenous structure but emerging evidence shows differentiation along the dorsoventral axis and even microdomains for functional and cellular markers. We have examined in two cell‐types of the hippocampal projection neurons, the dentate gyrus (DG) granule cells and CA3 pyramidal neurons, if the GABA‐activated tonic current density varied between the dorsal (septal) and the ventral (temporal) poles of the male mouse hippocampus. Tonic synaptic currents, arising from spontaneous and miniature inhibitory postsynaptic currents (sIPSC, mIPSC), and extrasynaptic tonic currents were evaluated. The results revealed different levels of sIPSC but not mIPSC density between the dorsal and ventral hippocampal neurons for both the DG granule cells and the CA3 pyramidal neurons. The extrasynaptic tonic current density was larger in the DG granule cells as compared to the CA3 pyramidal neurons but did not vary between the dorsal and ventral regions. IPSC bursting was observed in both cell‐types in the ventral hippocampus but was more common in the CA3 pyramidal neurons. Only in the dorsal DG granule cells was the level of the sIPSC and mIPSC density similar. The results indicate that the tonic GABAergic inhibition is particularly strong in the ventral hippocampal DG granule cells and enhanced in the dorsal as compared to the ventral hippocampal CA3 pyramidal neurons.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- extrasynaptic tonic current
- GABA
- GABAA receptor
- inhibitory transmission
- IPSC
- synaptic transmission
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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