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Tau aggregation and...
Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients – A PET/MR study
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- Marklund, Niklas (författare)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Enblad: Neurokirurgi,Department of Neuroscience, Neurosurgery, Uppsala, Uppsala University, Sweden. Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Neurosurgery, Lund, Sweden,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Vedung, Fredrik (författare)
- Uppsala University,Uppsala universitet,Enblad: Neurokirurgi,Department of Neuroscience, Neurosurgery, Uppsala, Uppsala University, Sweden
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- Lubberink, Mark (författare)
- Uppsala University,Uppsala universitet,Radiologi,Medical Physics, Uppsala University Hospital, Uppsala, Sweden. Department of Surgical sciences, Nuclear medicine and PET, Uppsala University, Sweden
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- Tegner, Yelverton, Professor emeritus (författare)
- Luleå University of Technology,Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Health Sciences, Luleå University of Technology, Sweden.
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- Johansson, Jakob (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård,Department of Surgical sciences, Anesthesiology, Uppsala University, Sweden
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- Blennow, Kaj (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Zetterberg, Henrik (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Fahlström, Markus (författare)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
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- Haller, Sven (författare)
- Uppsala University,Uppsala universitet,Radiologi,CIMC Ctr Imagerie Med Cornavin, Pl Cornavin 18, CH-1201 Geneva, Switzerland.,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden. CIMC - Centre d’Imagerie Médicale de Cornavin, Place de Cornavin 18, 1201 Genève, Switzerland
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- Stenson, Staffan (författare)
- Uppsala Univ Hosp, Rehabil Med PET Ctr, Dept Neurosci, Uppsala, Sweden.,Department of Neuroscience, Rehabilitation Medicine PET Centre, Uppsala University Hospital, Uppsala, Sweden
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- Larsson, Elna-Marie (författare)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
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- Wall, Anders (författare)
- Uppsala University,Uppsala universitet,Radiologi,Institutionen för läkemedelskemi,Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden. Department of Clinical Sciences Lund, Neurosurgery, Lund University 222 20 Lund, Sweden
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- Antoni, Gunnar (författare)
- Uppsala University,Uppsala universitet,Plattformen för Preklinisk PET-MRI,Preparativ läkemedelskemi,Department of Clinical Sciences Lund, Neurosurgery, Lund University 222 20 Lund, Sweden
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: NeuroImage. - : Elsevier. - 2213-1582. ; 30
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are associated with an increased risk for neurodegeneration. Autopsy findings of selected cohorts of long-term TBI survivors and rSRC athletes reveal increased tau aggregation and a persistent neuroinflammation. To assess in vivo tau aggregation and neuroinflammation in young adult TBI and rSRC cohorts, we evaluated 9 healthy controls (mean age 26 ± 5 years; 4 males, 5 females), 12 symptomatic athletes (26 ± 7 years; 6 males, 6 females) attaining ≥3 previous SRCs, and 6 moderate-to severe TBI patients (27 ± 7 years; 4 males, 2 females) in a combined positron emission tomography (PET)/magnetic resonance (MR) scanner ≥6 months post-injury. Dual PET tracers, [18F]THK5317 for tau aggregation and [11C]PK11195 for neuroinflammation/microglial activation, were investigated on the same day. The Repeated Battery Assessment of Neurological Status (RBANS) scores, used for cognitive evaluation, were lower in both the rSRC and TBI groups (p < 0.05). Neurofilament-light (NF-L) levels were increased in plasma and cerebrospinal fluid (CSF; p < 0.05), and serum tau levels lower, in TBI although not in rSRC. In rSRC athletes, PET imaging showed increased neuroinflammation in the hippocampus and tau aggregation in the corpus callosum. In TBI patients, tau aggregation was observed in thalami, temporal white matter and midbrain; widespread neuroinflammation was found e.g. in temporal white matter, hippocampus and corpus callosum. In mixed-sex cohorts of young adult athletes with persistent post-concussion symptoms and in TBI patients, increased tau aggregation and neuroinflammation are observed at ≥6 months post-injury using PET. Studies with extended clinical follow-up, biomarker examinations and renewed PET imaging are needed to evaluate whether these findings progress to a neurodegenerative disorder or if spontaneous resolution is possible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Traumatic brain injury
- sports-related concussion
- inflammation
- tau
- positron emission tomography (PET)
- Neurosurgery
- Neurokirurgi
- Neurosurgery
- Neurokirurgi
- Medicinsk vetenskap
- Inflammation
- Positron emission tomography (PET)
- Sports-related concussion
- Tau
- Traumatic brain injury
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Marklund, Niklas
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Vedung, Fredrik
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Lubberink, Mark
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Tegner, Yelverto ...
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Johansson, Jakob
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Blennow, Kaj
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Zetterberg, Henr ...
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Fahlström, Marku ...
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Haller, Sven
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Stenson, Staffan
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Larsson, Elna-Ma ...
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Wall, Anders
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Antoni, Gunnar
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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NeuroImage
- Av lärosätet
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Uppsala universitet
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Luleå tekniska universitet
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Lunds universitet
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Göteborgs universitet