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Sökning: onr:"swepub:oai:DiVA.org:uu-438340" > Subcortical surface...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009450naa a2200853 4500
001oai:DiVA.org:uu-438340
003SwePub
008210322s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4383402 URI
0247 a https://doi.org/10.1111/adb.128302 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chye, Yannu Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.4 aut
2451 0a Subcortical surface morphometry in substance dependence :b An ENIGMA addiction working group study
264 c 2019-11-20
264 1b WILEY,c 2020
338 a print2 rdacarrier
520 a While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a addiction
653 a structural MRI
653 a substance dependence
7001 a Mackey, Scottu Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.4 aut
7001 a Gutman, Boris A.u IIT, Biomed Engn, Chicago, IL 60616 USA.4 aut
7001 a Ching, Christopher R. K.u Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.4 aut
7001 a Batalla, Albertu Univ Utrecht, Dept Psychiat, Univ Med Ctr Utrecht, Brain Ctr, Utrecht, Netherlands.;Univ Barcelona, Dept Psychiat & Psychol, Hosp Clin, IDIBAPS,CIBERSAM,Inst Neurosci, Barcelona, Spain.4 aut
7001 a Blaine, Sarau Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.4 aut
7001 a Brooks, Samanthau Uppsala universitet,Schiöth: Funktionell farmakologi,Liverpool John Moores Univ, Sch Psychol, Fac Hlth, Liverpool L3 3AF, Merseyside, England.4 aut0 (Swepub:uu)sambr210
7001 a Caparelli, Elisabeth C.u NIDA, Neuroimaging Res Branch, Intramural Res Program, Baltimore, MD USA.4 aut
7001 a Cousijn, Jannau Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands.4 aut
7001 a Dagher, Alainu McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada.4 aut
7001 a Foxe, John J.u Univ Rochester, Sch Med & Dent, Dept Neurosci, Rochester, NY USA.;Univ Rochester, Sch Med & Dent, Ernest J Del Monte Inst Neurosci, Rochester, NY USA.4 aut
7001 a Goudriaan, Anna E.u Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Inst Addict Res, Amsterdam, Netherlands.;Arkin Mental Hlth Care, Dept Res & Qual Care, Amsterdam, Netherlands.4 aut
7001 a Hester, Robertu Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic, Australia.4 aut
7001 a Hutchison, Kentu Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.4 aut
7001 a Jahanshad, Nedau Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.4 aut
7001 a Kaag, Anne M.u Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands.4 aut
7001 a Korucuoglu, Ozlemu Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.4 aut
7001 a Li, Chiang-Shan R.u Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.4 aut
7001 a London, Edythe D.u Univ Calif Los Angeles, David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.4 aut
7001 a Lorenzetti, Valentinau Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.;Australian Catholic Univ, Sch Psychol, Fac Hlth Sci, Melbourne, Vic, Australia.4 aut
7001 a Luijten, Maartjeu Radboud Univ Nijmegen, Inst Behav Sci, Nijmegen, Netherlands.4 aut
7001 a Martin-Santos, Rociou Univ Barcelona, Dept Psychiat & Psychol, Hosp Clin, IDIBAPS,CIBERSAM,Inst Neurosci, Barcelona, Spain.4 aut
7001 a Meda, Shashwath A.u Hartford Hosp IOL, Olin Neuropsychiat Res Ctr, Hartford, CT USA.4 aut
7001 a Momenan, Rezau NIAAA, Clin NeuroImaging Res Core, Div Intramural Clin & Biol Res, Bethesda, MD USA.4 aut
7001 a Morales, Angelicau Univ Calif Los Angeles, David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.4 aut
7001 a Orr, Catherineu Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.4 aut
7001 a Paulus, Martin P.u VA San Diego Healthcare Syst, San Diego, CA USA.;Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;Laureate Inst Brain Res, Tulsa, OK USA.4 aut
7001 a Pearlson, Godfreyu Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.4 aut
7001 a Reneman, Liesbethu Locat AMC, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.4 aut
7001 a Schmaal, Lianneu Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.;Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia.4 aut
7001 a Sinha, Rajitau Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.4 aut
7001 a Solowij, Nadiau Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.;Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.;Australian Ctr Cannabinoid Clin & Res Excellence, New Lambton Hts, NSW, Australia.4 aut
7001 a Stein, Dan J.u Univ Cape Town, SA MRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Inst Neurosci, Cape Town, South Africa.4 aut
7001 a Stein, Elliot A.u NIDA, Neuroimaging Res Branch, Intramural Res Program, Baltimore, MD USA.4 aut
7001 a Tang, Deborahu McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada.4 aut
7001 a Uhlmann, Anneu Univ Cape Town, Fac Hlth Sci, Dept Psychiat & Mental Hlth, Cape Town, South Africa.4 aut
7001 a van Holst, Ruthu Univ Amsterdam, Dept Psychiat, Amsterdam, Netherlands.4 aut
7001 a Veltman, Dick J.u Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.4 aut
7001 a Verdejo-Garcia, Antoniou Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.4 aut
7001 a Wiers, Reinout W.u Univ Amsterdam, Addict Dev & Psychopathol ADAPT Lab, Amsterdam, Netherlands.4 aut
7001 a Yuecel, Muratu Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.4 aut
7001 a Thompson, Paul M.u Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.4 aut
7001 a Conrod, Patriciau Univ Montreal, Dept Psychiat, CHU Ste Justine Hosp, Montreal, PQ, Canada.4 aut
7001 a Garavan, Hughu Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.4 aut
7102 a Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.b Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.4 org
7730 t Addiction Biologyd : WILEYg 25:6q 25:6x 1355-6215x 1369-1600
8564 u https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1111/adb.12830
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438340
8564 8u https://doi.org/10.1111/adb.12830

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