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Sökning: onr:"swepub:oai:DiVA.org:uu-439118" > Null association be...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005545naa a2200517 4500
001oai:DiVA.org:uu-439118
003SwePub
008210330s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144731278
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4391182 URI
0247 a https://doi.org/10.1111/cea.137392 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1447312782 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Feng, Qiu Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.4 aut
2451 0a Null association between serum 25-hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non-allergic rhinitis :b A Mendelian randomization study
264 c 2020-09-28
264 1b John Wiley & Sons,c 2021
338 a print2 rdacarrier
520 a Background Previous observational studies have not found a conclusive association between serum 25-hydroxyvitamin D (25(OH)D) levels and allergic rhinitis (AR) or allergic sensitization (AS). Objective To investigate a causal association between 25(OH)D levels with risk of AR and AS, using a two-sample Mendelian randomization (MR) approach. Methods Seven single nucleotide polymorphisms (SNPs), previously shown to be associated with serum 25(OH)D levels, were identified as instrumental variables. The primary outcome was AR, and the secondary outcomes were AS and non-allergic rhinitis (NAR). The genome-wide association (GWA) summary statistics of the outcomes were obtained from two cohort studies (EAGLE Consortium and UK Biobank). An MR analysis with random-effects inverse-variance weighted method was performed as the primary analysis to estimate overall effect size (odds ratio [OR] and 95% confidence interval [CI]). Sensitivity analysis using weighted median method and MR-Egger regression method was conducted. A subgroup analysis based on 25(OH)D synthesis-related SNPs was further applied. Results Serum 25(OH)D levels were not causally associated with risk of AR (OR: 0.960; 95% CI: 0.779-1.184), AS (OR: 1.059; 95% CI: 0.686 to 1.634) or NAR (OR: 0.937; 95% CI: 0.588-1.491). Subgroup analysis also showed null association between 25(OH)D synthesis-related SNPs and the outcomes. Sensitivity analyses yielded similar results. Conclusions and Clinical Relevance This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European-ancestry population. This argues against the previous postulation that vitamin D supplementation is effective in prevention of allergic diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a 25-hydroxyvitamin D
653 a allergic rhinitis
653 a allergic sensitization
653 a causation
653 a Mendelian randomization
653 a vitamin D
7001 a Bonnelykke, Klausu Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark.4 aut
7001 a Ek, Weronica Eu Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)werek336
7001 a Chawes, Bo L.u Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark.4 aut
7001 a Yuan, Shuaiu Karolinska Institutet4 aut
7001 a Cheung, Ching Lungu Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, LKS Fac Med, Ctr Genom Sci, Pokfulam, Hong Kong, Peoples R China.4 aut
7001 a Li, Gloria H. Y.u Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China.4 aut
7001 a Leung, Raymond Y. H.u Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China.4 aut
7001 a Cheung, Bernard M. Y.u Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, Inst Cardiovasc Sci & Med, Pokfulam, Hong Kong, Peoples R China.4 aut
7102 a Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.b Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark.4 org
7730 t Clinical and Experimental Allergyd : John Wiley & Sonsg 51:1, s. 78-86q 51:1<78-86x 0954-7894x 1365-2222
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439118
8564 8u https://doi.org/10.1111/cea.13739
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144731278

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