Sökning: onr:"swepub:oai:DiVA.org:uu-440155" > A longitudinal stud...
Fältnamn | Indikatorer | Metadata |
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000 | 04961naa a2200493 4500 | |
001 | oai:DiVA.org:uu-440155 | |
003 | SwePub | |
008 | 210426s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146029703 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4401552 URI |
024 | 7 | a https://doi.org/10.1016/j.envpol.2020.1163332 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460297032 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Akhtar, Evanau Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut |
245 | 1 0 | a A longitudinal study of rural Bangladeshi children with long-term arsenic and cadmium exposures and biomarkers of cardiometabolic diseases |
264 | 1 | b Elsevier,c 2021 |
338 | a print2 rdacarrier | |
520 | a There is growing interest in understanding the contribution of environmental toxicant exposure in early life to development of cardiometabolic diseases (CMD) in adulthood. We aimed to assess associations of early life exposure to arsenic and cadmium with biomarkers of CMD in children in rural Bangladesh. From a longitudinal mother-child cohort in Matlab, Bangladesh, we followed up 540 pairs. Exposure to arsenic (U–As) and cadmium (U–Cd) was assessed by concentrations in urine from mothers at gestational week 8 (GW8) and children at ages 4.5 and 9 years. Blood pressure and anthropometric indices were measured at 4.5 and 9 years. Metabolic markers (lipids, glucose, hemoglobin A1c, adipokines, estimated glomerular filtration rate (eGFR) were determined in plasma/blood of 9 years old children. In linear regression models, adjusted for child sex, age, height-for-age z score (HAZ), BMI-for-age z score (BAZ), socioeconomic status (SES) and maternal education, each doubling of maternal and early childhood U–Cd was associated with 0.73 and 0.82 mmHg increase in systolic blood pressure (SBP) respectively. Both early and concurrent childhood U–Cd was associated with diastolic (D)BP (β = 0.80 at 4.5 years; β = 0.75 at 9 years). Each doubling of U–Cd at 9 years was associated with decrements of 4.98 mg/dL of total cholesterol (TC), 1.75 mg/dL high-density lipoprotein (HDL), 3.85 mg/dL low-density lipoprotein (LDL), 0.43 mg/dL glucose and 4.29 units eGFR. Each doubling of maternal U–Cd was associated with a decrement of 1.23 mg/dL HDL. Both maternal and childhood U–As were associated with decrement in TC and HDL. Multiple comparisons were checked with family-wise error rate Bonferroni-type-approach. The negative associations of arsenic and cadmium with biomarkers of CMD in preadolescent children indicated influence of both metal(loid)s on fat and carbohydrate metabolism, while cadmium additionally influenced kidney function and BP. Thus, fewer outcomes were associated with U–As compared to U–Cd at preadolescence. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
653 | a Arsenic | |
653 | a Cadmium | |
653 | a Prenatal and childhood exposure | |
653 | a Cardiometabolic biomarkers | |
700 | 1 | a Roy, Anjan Kumaru Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut |
700 | 1 | a Haq, Md Ahsanulu Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut |
700 | 1 | a von Ehrenstein, Ondine S.u Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci & Epidemiol, Los Angeles, CA 90024 USA4 aut |
700 | 1 | a Ahmed, Sultanu Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut |
700 | 1 | a Vahter, Marieu Karolinska Institutet4 aut |
700 | 1 | a Ekström, Eva-Charlotte,d 1956-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)loeks254 |
700 | 1 | a Kippler, Mariau Karolinska Institutet4 aut |
700 | 1 | a Wagatsuma, Yukikou Univ Tsukuba, Fac Med, Dept Clin Trial & Clin Epidemiol, Tsukuba, Ibaraki, Japan4 aut |
700 | 1 | a Raqib, Rubhanau Icddr B, Infect Dis Div, Dhaka 1212, Bangladesh4 aut |
710 | 2 | a Icddr B, Infect Dis Div, Dhaka 1212, Bangladeshb Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci & Epidemiol, Los Angeles, CA 90024 USA4 org |
773 | 0 | t Environmental Pollutiond : Elsevierg 271q 271x 0269-7491x 1873-6424 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440155 |
856 | 4 8 | u https://doi.org/10.1016/j.envpol.2020.116333 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146029703 |
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