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Dynamic sex chromos...
Dynamic sex chromosome expression in Drosophila male germ cells
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- Mahadevaraju, Sharvani (författare)
- NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA.
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- Fear, Justin M. (författare)
- NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA.
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- Akeju, Miriam (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Galletta, Brian J. (författare)
- NHLBI, Cell Biol & Physiol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Pinheiro, Mara M. L. S. (författare)
- Univ Sao Paulo, Dept Genet & Evolutionary Biol, Inst Biosci, BR-05508090 Sao Paulo, SP, Brazil.
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- Avelino, Camila C. (författare)
- Univ Sao Paulo, Dept Genet & Evolutionary Biol, Inst Biosci, BR-05508090 Sao Paulo, SP, Brazil.
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- Cabral-de-Mello, Diogo C. (författare)
- UNESP Univ Estadual Paulista, Dept Biol Geral & Aplicada, Inst Biociencias IB, BR-13506900 Rio Claro, SP, Brazil.
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- Conlon, Katie (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Dell'Orso, Stafania (författare)
- NIAMSD, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA.
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- Demere, Zelalem (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Mansuria, Kush (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Mendonca, Carolina A. (författare)
- Univ Sao Paulo, Dept Genet & Evolutionary Biol, Inst Biosci, BR-05508090 Sao Paulo, SP, Brazil.
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- Palacios Gimenez, Octavio Manuel (författare)
- Uppsala universitet,Evolutionsbiologi,Systematisk biologi,Univ Sao Paulo, Dept Genet & Evolutionary Biol, Inst Biosci, BR-05508090 Sao Paulo, SP, Brazil.
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- Ross, Eli (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Savery, Max (författare)
- NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA.
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- Yu, Kevin (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Smith, Harold E. (författare)
- NIDDK, Genom Core, NIH, Bethesda, MD 20892 USA.
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- Sartorelli, Vittorio (författare)
- NIAMSD, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA.
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- Yang, Haiwang (författare)
- NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA.;Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA.
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- Rusan, Nasser M. (författare)
- NHLBI, Cell Biol & Physiol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Vibranovski, Maria D. (författare)
- Univ Sao Paulo, Dept Genet & Evolutionary Biol, Inst Biosci, BR-05508090 Sao Paulo, SP, Brazil.
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- Matunis, Erika (författare)
- Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA.
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- Oliver, Brian (författare)
- NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA.
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NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA Johns Hopkins Univ, Sch Med, Dept Cell Biol, 725 N Wolfe St, Baltimore, MD 21205 USA. (creator_code:org_t)
- 2021-02-09
- 2021
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Given their copy number differences and unique modes of inheritance, the evolved gene content and expression of sex chromosomes is unusual. In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense mechanism against insertions into unpaired chromatin. In addition to current sex chromosomes, Drosophila has a small gene-poor X-chromosome relic (4(th)) that re-acquired autosomal status. Here we use single cell RNA-Seq on fly larvae to demonstrate that the single X and pair of 4(th) chromosomes are specifically inactivated in primary spermatocytes, based on measuring all genes or a set of broadly expressed genes in testis we identified. In contrast, genes on the single Y chromosome become maximally active in primary spermatocytes. Reduced X transcript levels are due to failed activation of RNA-Polymerase-II by phosphorylation of Serine 2 and 5. Sex chromosome gene content and expression is unusual. Here the authors use single cell RNA-Seq on Drosophila larvae to demonstrate that the single X and pair of 4th chromosomes are specifically inactivated in primary spermatocytes, while genes on the single Y chromosome become maximally active in primary spermatocytes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Mahadevaraju, Sh ...
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Fear, Justin M.
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Akeju, Miriam
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Galletta, Brian ...
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Pinheiro, Mara M ...
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Avelino, Camila ...
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visa fler...
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Cabral-de-Mello, ...
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Conlon, Katie
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Dell'Orso, Stafa ...
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Demere, Zelalem
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Mansuria, Kush
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Mendonca, Caroli ...
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Palacios Gimenez ...
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Ross, Eli
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Savery, Max
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Yu, Kevin
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Smith, Harold E.
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Sartorelli, Vitt ...
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Yang, Haiwang
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Rusan, Nasser M.
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Vibranovski, Mar ...
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Matunis, Erika
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Oliver, Brian
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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Nature Communica ...
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Uppsala universitet