Sökning: onr:"swepub:oai:DiVA.org:uu-440708" >
Validity and reliab...
Validity and reliability of extrastriatal [C-11]raclopride binding quantification in the living human brain
-
- Svensson, Jonas E. (författare)
- Karolinska Institutet
-
- Schain, Martin (författare)
- Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark.
-
- Plaven-Sigray, Pontus (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm Cty Council, Stockholm Hlth Care Serv, SE-17176 Stockholm, Sweden.
-
visa fler...
-
- Cervenka, Simon (författare)
- Karolinska Institutet
-
- Tiger, Mikael (författare)
- Karolinska Institutet
-
- Nord, Magdalena (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm Cty Council, Stockholm Hlth Care Serv, SE-17176 Stockholm, Sweden.
-
- Halldin, Christer (författare)
- Karolinska Institutet
-
- Farde, Lars (författare)
- Karolinska Institutet
-
- Lundberg, Johan (författare)
- Karolinska Institutet
-
visa färre...
-
Karolinska Institutet Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark (creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
- 2019
- Engelska.
-
Ingår i: NeuroImage. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1053-8119 .- 1095-9572. ; 202
- Relaterad länk:
-
https://www.biorxiv....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- [C-11]raclopride is a well established PET tracer for the quantification of dopamine 2/3 receptors (D2/3R) in the striatum. Outside of the striatum the receptor density is up to two orders of magnitude lower. In contrast to striatal binding, the characteristics of extrastriatal [C-11]raclopride binding quantification has not been thoroughly described. Still, binding data for e.g., neocortex is frequently reported in the scientific literature. Here we evaluate the validity and reliability of extrastriatal [C-11]raclopride binding quantification. Two sets of healthy control subjects were examined with HRRT and [C-11]raclopride: (i) To assess the validity of extrastriatal [C-11]raclopride binding estimates, eleven subjects were examined at baseline and after dosing with quetiapine, a D2/3R antagonist. (ii) To assess test-retest repeatability, nine subjects were examined twice. Non displaceable binding potential (BPND) was quantified using the simplified reference tissue model with cerebellum as reference. Quetiapine dosing was associated with decrease in [C-11]raclopride BPND in temporal cortex (18 +/- 17% occupancy) and thalamus (20 +/- 17%), but not in frontal cortex. Extrastriatal occupancy was lower than in putamen (51 +/- 4%). The mean absolute variation was 4-7% in the striatal regions, 17% in thalamus, and 13-59% in cortical regions. Our data indicate that [C-11]raclopride PET, quantified using cerebellum as reference, is not a suitable tool to measure D2/3R in extrastriatal regions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Dopamine
- Extrastriatal
- Positron emission tomography
- Raclopride
- Reference region
- Occupancy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas