Sökning: onr:"swepub:oai:DiVA.org:uu-440805" > In vivo coupling of...
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000 | 05509naa a2200673 4500 | |
001 | oai:DiVA.org:uu-440805 | |
003 | SwePub | |
008 | 210420s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:230426064 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4408052 URI |
024 | 7 | a https://doi.org/10.1016/j.dadm.2018.08.0052 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2304260642 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mak, Elijahu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
245 | 1 0 | a In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease |
264 | c 2018-09-17 | |
264 | 1 | b Wiley,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Introduction: The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.Methods: We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid β (Aβ) status ([11C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups.Results: Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy.Discussion: These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Amyloid | |
653 | a Atrophy | |
653 | a Cortical thickness | |
653 | a MRI | |
653 | a Positron emission tomography | |
653 | a Tau | |
700 | 1 | a Bethlehem, Richard A Iu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Romero-Garcia, Rafaelu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Cervenka, Simonu Karolinska Institutet4 aut0 (Swepub:uu)simce160 |
700 | 1 | a Rittman, Timothyu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Gabel, Silvyu Department of Psychiatry, University of Cambridge, Cambridge, UK; Laboratory for Cognitive Neurology, University of Leuven, Leuven, Belgium4 aut |
700 | 1 | a Surendranathan, Ajenthanu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Bevan-Jones, Richard Wu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Passamonti, Lucau Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Vázquez Rodríguez, Patriciau Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Su, Liu Department of Psychiatry, University of Cambridge, Cambridge, UK; China‐UK Centre for Cognition and Ageing Research, Southwest University, Chongqing, China4 aut |
700 | 1 | a Arnold, Robertu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Williams, Guy Bu Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Hong, Young Tu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Fryer, Tim Du Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Aigbirhio, Franklin Iu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Rowe, James Bu Medical Research Council, and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a O'Brien, John Tu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut |
710 | 2 | a Karolinska Institutetb Department of Psychiatry, University of Cambridge, Cambridge, UK4 org |
773 | 0 | t Alzheimer's & dementia (Amsterdam, Netherlands)d : Wileyg 10, s. 678-687q 10<678-687x 2352-8729 |
856 | 4 | u https://doi.org/10.1016/j.dadm.2018.08.005y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1546019/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.dadm.2018.08.005 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440805 |
856 | 4 8 | u https://doi.org/10.1016/j.dadm.2018.08.005 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:230426064 |
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