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Proteostasis of Isl...
Proteostasis of Islet Amyloid Polypeptide : A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes
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- Milardi, Danilo (författare)
- CNR, Ist Cristallog, I-95126 Catania, Italy
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- Gazit, Ehud (författare)
- Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, Shmunis Sch Biomed & Canc Res, George S Wise Fac Life Sci, IL-6997801 Tel Aviv, Israel
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- Radford, Sheena E. (författare)
- Univ Leeds, Astbury Ctr Struct Mol Biol, Sch Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England
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- Xu, Yong (författare)
- Univ Leeds, Astbury Ctr Struct Mol Biol, Sch Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England
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- Gallardo, Rodrigo U. (författare)
- Univ Leeds, Astbury Ctr Struct Mol Biol, Sch Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England
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- Caflisch, Amedeo (författare)
- Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland
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- Westermark, Gunilla T. (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Westermark, Per (författare)
- Uppsala universitet,Klinisk och experimentell patologi
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- La Rosa, Carmelo (författare)
- Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
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- Ramamoorthy, Ayyalusamy (författare)
- Univ Michigan, Dept Chem Biomed Engn Macromol Sci & Engn, Biophys, Ann Arbor, MI 41809 USA
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(creator_code:org_t)
- 2021-01-11
- 2021
- Engelska.
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Ingår i: Chemical Reviews. - : American Chemical Society (ACS). - 0009-2665 .- 1520-6890. ; 121:3, s. 1845-1893
- Relaterad länk:
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https://eprints.whit...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation pathways of this hormone. Recent studies have reported on the importance of early oligomeric intermediates, the many roles of their interactions with lipid membrane, pH, insulin, and zinc on the mechanism of aggregation of hIAPP. The challenges posed by the transient nature of amyloid oligomers, their structural heterogeneity, and the complex nature of their interaction with lipid membranes have resulted in the development of a wide range of biophysical and chemical approaches to characterize the aggregation process. While the cellular processes and factors activating hIAPP-mediated cytotoxicity are still not clear, it has recently been suggested that its impaired turnover and cellular processing by proteasome and autophagy may contribute significantly toward toxic hIAPP accumulation and, eventually, β-cell death. Therefore, studies focusing on the restoration of hIAPP proteostasis may represent a promising arena for the design of effective therapies. In this review we discuss the current knowledge of the structures and pathology associated with hIAPP self-assembly and point out the opportunities for therapy that a detailed biochemical, biophysical, and cellular understanding of its aggregation may unveil.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Milardi, Danilo
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Gazit, Ehud
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Radford, Sheena ...
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Xu, Yong
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Gallardo, Rodrig ...
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Caflisch, Amedeo
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Westermark, Guni ...
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Westermark, Per
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La Rosa, Carmelo
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Ramamoorthy, Ayy ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Chemical Reviews
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Uppsala universitet