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The overlap of gene...
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Strawbridge, Rona J.Karolinska Institutet,Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.;Hlth Data Res, London, England.;Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
(författare)
The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-01-12
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Springer Nature,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-441151
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441151URI
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https://doi.org/10.1038/s41598-020-79964-xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146095064URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Understanding why individuals with severe mental illness (Schizophrenia, Bipolar Disorder and Major Depressive Disorder) have increased risk of cardiometabolic disease (including obesity, type 2 diabetes and cardiovascular disease), and identifying those at highest risk of cardiometabolic disease are important priority areas for researchers. For individuals with European ancestry we explored whether genetic variation could identify sub-groups with different metabolic profiles. Loci associated with schizophrenia, bipolar disorder and major depressive disorder from previous genome-wide association studies and loci that were also implicated in cardiometabolic processes and diseases were selected. In the IMPROVE study (a high cardiovascular risk sample) and UK Biobank (general population sample) multidimensional scaling was applied to genetic variants implicated in both psychiatric and cardiometabolic disorders. Visual inspection of the resulting plots used to identify distinct clusters. Differences between these clusters were assessed using chi-squared and Kruskall-Wallis tests. In IMPROVE, genetic loci associated with both schizophrenia and cardiometabolic disease (but not bipolar disorder or major depressive disorder) identified three groups of individuals with distinct metabolic profiles. This grouping was replicated within UK Biobank, with somewhat less distinction between metabolic profiles. This work focused on individuals of European ancestry and is unlikely
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Johnston, Keira J. A.Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.;Univ Edinburgh, Coll Med & Vet Med, Mol Genet & Populat Hlth Sci, Edinburgh, Midlothian, Scotland.;Univ Glasgow, Sch Life Sci, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.
(författare)
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Bailey, Mark E. S.Univ Glasgow, Sch Life Sci, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.
(författare)
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Baldassarre, DamianoUniv Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.;IRCCS, Ctr Cardiol Monzino, Milan, Italy.
(författare)
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Cullen, BredaUniv Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Eriksson, PerKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
(författare)
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deFaire, UlfKarolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
(författare)
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Ferguson, AmyUniv Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.;Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
(författare)
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Gigante, BrunaKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
(författare)
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Giral, PhilippeGrp Hop Pitie Salpetriere, AP HP, Unites Prevent Cardiovasc, Serv Endocrinol Metab, Paris, France.
(författare)
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Graham, NicholasUniv Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Hamsten, AndersKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
(författare)
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Humphries, Steve E.UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England.
(författare)
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Kurl, SudhirUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
(författare)
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Lyall, Donald M.Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Lyall, Laura M.Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Pell, Jill P.Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Pirro, MatteoUniv Perugia, Dept Clin & Expt Med, Internal Med Angiol & Arteriosclerosis Dis, Perugia, Italy.
(författare)
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Savonen, KaiKuopio Res Inst Exercise Med, Fdn Res Hlth Exercise & Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland.
(författare)
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Smit, Andries J.Univ Med Ctr Groningen, Dept Med, Groningen, Netherlands.;Univ Groningen, Groningen, Netherlands.
(författare)
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Tremoli, ElenaIRCCS, Ctr Cardiol Monzino, Milan, Italy.
(författare)
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Tomainen, Tomi-PekkaUniv Eastern Finland, Dept Med, Publ Hlth & Clin Nutr, Kupiou, Finland.
(författare)
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Veglia, FabrizioIRCCS, Ctr Cardiol Monzino, Milan, Italy.
(författare)
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Ward, JoeyUniv Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Sennblad, BengtUppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab(Swepub:uu)bengtsb
(författare)
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Smith, Daniel J.Univ Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
(författare)
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Karolinska InstitutetUniv Glasgow, Inst Hlth & Wellbeing, Publ Hlth, Room 111,1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.;Hlth Data Res, London, England.;Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: Springer Nature11:12045-2322
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Till lärosätets databas
- Av författaren/redakt...
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Strawbridge, Ron ...
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Johnston, Keira ...
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Bailey, Mark E. ...
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Baldassarre, Dam ...
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Cullen, Breda
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Eriksson, Per
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visa fler...
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deFaire, Ulf
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Ferguson, Amy
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Gigante, Bruna
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Giral, Philippe
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Graham, Nicholas
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Hamsten, Anders
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Humphries, Steve ...
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Kurl, Sudhir
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Lyall, Donald M.
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Lyall, Laura M.
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Pell, Jill P.
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Pirro, Matteo
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Savonen, Kai
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Smit, Andries J.
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Tremoli, Elena
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Tomainen, Tomi-P ...
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Veglia, Fabrizio
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Ward, Joey
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Sennblad, Bengt
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Smith, Daniel J.
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