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Prospective data-dr...
Prospective data-driven respiratory gating of [Ga-68]Ga-DOTATOC PET/CT
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- Sigfridsson, Jonathan (författare)
- Uppsala universitet,Radiologi
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- Lindström, Elin (författare)
- Uppsala universitet,Radiologi
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- Iyer, Victor (författare)
- Uppsala universitet,Radiologi
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- Holstensson, Maria (författare)
- Karolinska Institutet
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- Velikyan, Irina, 1966- (författare)
- Uppsala universitet,Radiologi
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- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Radiologi
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2021-03-31
- 2021
- Engelska.
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Ingår i: EJNMMI Research. - : Springer Nature. - 2191-219X. ; 11
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://ejnmmires.sp...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Aim: The aim of this prospective study was to evaluate a data-driven gating software's performance, in terms of identifying the respiratory signal, comparing [Ga-68]Ga-DOTATOC and [F-18]FDG examinations. In addition, for the [Ga-68]Ga-DOTATOC examinations, tracer uptake quantitation and liver lesion detectability were assessed.Methods: Twenty-four patients with confirmed or suspected neuroendocrine tumours underwent whole-body [Ga-68]Ga-DOTATOC PET/CT examinations. Prospective DDG was applied on all bed positions and respiratory motion correction was triggered automatically when the detected respiratory signal exceeded a certain threshold (R value >= 15), at which point the scan time for that bed position was doubled. These bed positions were reconstructed with quiescent period gating (QPG), retaining 50% of the total coincidences. A respiratory signal evaluation regarding the software's efficacy in detecting respiratory motion for [Ga-68]Ga-DOTATOC was conducted and compared to [F-18]FDG data. Measurements of SUVmax, SUVmean, and tumour volume were performed on [Ga-68]Ga-DOTATOC PET and compared between gated and non-gated images.Results: The threshold of R >= 15 was exceeded and gating triggered on mean 2.1 bed positions per examination for [Ga-68]Ga-DOTATOC as compared to 1.4 for [F-18]FDG. In total, 34 tumours were evaluated in a quantitative analysis. An increase of 25.3% and 28.1%, respectively, for SUVmax (P < 0.0001) and SUVmean (P < 0.0001), and decrease of 21.1% in tumour volume (P < 0.0001) was found when DDG was applied.Conclusions: High respiratory signal was exclusively detected in bed positions where respiratory motion was expected, indicating reliable performance of the DDG software on [Ga-68]Ga-DOTATOC PET/CT. DDG yielded significantly higher SUVmax and SUVmean values and smaller tumour volumes, as compared to non-gated images.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- PET
- CT
- DOTATOC
- Respiratory gating
- Data-driven gating
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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