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Disruption of innat...
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Agelidis, AlexUniv Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-04-08
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American Society For Clinical Investigation,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-442734
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442734URI
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https://doi.org/10.1172/jci.insight.144255DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The drive to withstand environmental stresses and defend against invasion is a universal trait extant in all forms of life. While numerous canonical signaling cascades have been characterized in detail, it remains unclear how these pathways interface to generate coordinated responses to diverse stimuli. To dissect these connections, we followed heparanase (HPSE), a protein best known for its endoglycosidic activity at the extracellular matrix but recently recognized to drive various forms of late-stage disease through unknown mechanisms. Using herpes simplex virus-1 (HSV-1) infection as a model cellular perturbation, we demonstrate that HPSE acts beyond its established enzymatic role to restrict multiple forms of cell-intrinsic defense and facilitate host cell reprogramming by the invading pathogen. We reveal that cells devoid of HPSE are innately resistant to infection and counteract viral takeover through multiple amplified defense mechanisms. With a unique grasp of the fundamental processes of transcriptional regulation and cell death, HPSE represents a potent cellular intersection with broad therapeutic potential.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Turturice, Benjamin A.Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Div Pulm Crit Care Sleep & Allergy, Dept Med, Chicago, IL 60612 USA.
(författare)
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Suryawanshi, Rahul K.Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Yadavalli, TejabhiramUniv Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Jaishankar, DineshUniv Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.;Northwestern Univ, Dept Dermatol, Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA.
(författare)
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Ames, JoshuaUniv Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Hopkins, JamesUniv Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Koujah, LuliaUniv Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Patil, Chandrashekhar D.Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Hadigal, Satvik R.Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Kyzar, Evan J.Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA.
(författare)
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Campeau, AnaamikaUCSD, Dept Pharmacol, La Jolla, CA USA.;UCSD, Skaggs Sch Pharm, La Jolla, CA USA.
(författare)
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Wozniak, Jacob M.UCSD, Dept Pharmacol, La Jolla, CA USA.;UCSD, Skaggs Sch Pharm, La Jolla, CA USA.
(författare)
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Gonzalez, David J.UCSD, Dept Pharmacol, La Jolla, CA USA.;UCSD, Skaggs Sch Pharm, La Jolla, CA USA.
(författare)
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Vlodavsky, IsraelTechnion, Technion Integrated Canc Ctr TICC, Rappaport Fac Med, Haifa, Israel.
(författare)
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Li, Jin-PingUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)jinpili
(författare)
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Perkins, David L.Univ Illinois, Div Nephrol, Dept Med, Chicago, IL 60612 USA.;Univ Illinois, Dept Surg, Chicago, IL 60612 USA.
(författare)
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Finn, Patricia W.Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Div Pulm Crit Care Sleep & Allergy, Dept Med, Chicago, IL 60612 USA.
(författare)
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Shukla, DeepakUniv Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
(författare)
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Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;Univ Illinois, Div Pulm Crit Care Sleep & Allergy, Dept Med, Chicago, IL 60612 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JCI Insight: American Society For Clinical Investigation6:72379-3708
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Till lärosätets databas
- Av författaren/redakt...
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Agelidis, Alex
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Turturice, Benja ...
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Suryawanshi, Rah ...
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Yadavalli, Tejab ...
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Jaishankar, Dine ...
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Ames, Joshua
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visa fler...
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Hopkins, James
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Koujah, Lulia
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Patil, Chandrash ...
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Hadigal, Satvik ...
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Kyzar, Evan J.
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Campeau, Anaamik ...
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Wozniak, Jacob M ...
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Gonzalez, David ...
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Vlodavsky, Israe ...
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Li, Jin-Ping
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Perkins, David L ...
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Finn, Patricia W ...
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Shukla, Deepak
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