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Limited Genetic Ove...
Limited Genetic Overlap Between Overt Hashimoto's Thyroiditis and Graves' Disease in Twins : A Population-based Study
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- Skov, Jakob (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden.;Karlstad Cent Hosp, Dept Med, SE-65230 Karlstad, Sweden
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- Calissendorff, Jan (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, Inflammat & Infect Theme, SE-17176 Stockholm, Sweden
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- Eriksson, Daniel (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk genetik och genomik,Karolinska Inst, Dept Med Solna, SE-17176 Stockholm, Sweden
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- Magnusson, Patrik (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
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- Kampe, Olle (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Endocrinol, Inflammat & Infect Theme, SE-17176 Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, SE-17176 Stockholm, Sweden.;Univ Bergen, KG Jebsen Ctr Autoimmune Dis, Bergen, Norway
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- Bensing, Sophie (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, Inflammat & Infect Theme, SE-17176 Stockholm, Sweden
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
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Karolinska Institutet Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden;Karlstad Cent Hosp, Dept Med, SE-65230 Karlstad, Sweden (creator_code:org_t)
- 2020-12-31
- 2021
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 106:4, s. 1101-1110
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: Hashimoto's thyroiditis (HT) and Graves' disease (GD) are known to coaggregate in families, but the magnitude and nature of a shared etiology is unknown.Objectives: To estimate the shared genetic influence on overt HT and GD and to examine if the heritability differs between men and women. Design, setting, and patients: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swedish twins. By comparing intra-class and cross-twin cross-trait correlations in dizygotic and monozygotic twins, we calculated heritability and the proportions thereof shared between the diseases. Univariate estimates of heritability were calculated by sex.Results: The heritability for HT and GD was 65% (95% CI, 61-70) and 63% (95% CI, 55-72), respectively. The genetic correlation was 0.35 (95% CI, 0.20-0.50) and shared genetic effects accounted for 8% of the variance for both HT and GD. Univariate heritability was significantly higher in men than in women for HT (90% vs 60%, P < 0.001) but not for GD (79% vs 63%, P = 0.085).Conclusions: From a genetic perspective, HT and GD appear to be only modestly related diseases. Hence, the term "autoimmune thyroid disease," used to cluster these disorders, may have limited validity in a genetic context. Moreover, the mechanisms contributing to HT are partly different for the sexes, with genetic components more important in men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- hypothyroidism
- hyperthyroidism
- twin studies
- genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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