Sökning: onr:"swepub:oai:DiVA.org:uu-444914" >
Insulin-like Growth...
Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture : A Mendelian Randomization Study
-
- Yuan, Shuai (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17165 Stockholm, Sweden
-
- Wan, Zi-Hao (författare)
- Chinese Univ Hong Kong, Fac Med, Dept Orthopaed & Traumatol, Hong Kong 999077, Peoples R China
-
- Cheng, Shi-Le (författare)
- Wuhan Univ, Renmin Hosp, Dept Orthoped Surg, Wuhan 430060, Peoples R China
-
visa fler...
-
- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Medicinsk epidemiologi
-
- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17165 Stockholm, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2021-01-19
- 2021
- Engelska.
-
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 106:4, s. 1552-1558
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Context: The associations of circulating insulin-like growth factor-1 (IGF-1) levels with bone mineral density and fracture risk are inconclusive in observational studies.Objective: We conducted a mendelian randomization study to assess the associations of serum IGF-1 levels with estimated bone mineral density (eBMD) and fracture.Methods: Genetic instruments for IGF-1 were selected at the genome-wide significance level (P < 5 x 10(-8)) from a genome-wide association study including 358 072 individuals of European ancestry. Summary-level data for eBMD (426 824 individuals) and fracture (53 184 fracture cases and 373 611 noncases) were obtained from the UK Biobank study. Univariable and multivariable mendelian randomization analyses methods were used to estimate the associations of IGF-1 with eBMD and fracture. The main outcome measure included the change of eBMD and odds ratio of fracture per genetically predicted 1-SD increase of serum IGF-1 levels.Results: For 1-SD increase in IGF-1, the change of eBMD levels was 0.04 g/cm(2) (95% CI, 0.01-0.07; P = .011) and the odds ratio of fracture was 0.94 (95% CI, 0.91-0.98; P = .003). The associations persisted with similar magnitude after adjustment for height. The association was consistent for fracture but not for eBMD after excluding genetic instruments that might directly influence these outcomes. The association between IGF-1 and fracture was somewhat attenuated after adjustment for eBMD (odds ratio 0.96; 95% CI, 0.92-0.99; P = .012).Conclusion: The present study supports a role for IGF-1 in preventing fracture, possibly and partly mediated by greater bone mineral density.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- insulin-like growth factor-1
- bone mineral density
- fracture
- causal inference
- mendelian randomization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas