Sökning: onr:"swepub:oai:DiVA.org:uu-447923" > Endocrine, metaboli...
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000 | 06557naa a2200637 4500 | |
001 | oai:DiVA.org:uu-447923 | |
003 | SwePub | |
008 | 210823s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146778306 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4479232 URI |
024 | 7 | a https://doi.org/10.1016/j.reprotox.2021.04.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1467783062 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Alarcon, Soniau Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut |
245 | 1 0 | a Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) :b A postnatal follow-up study in rats |
264 | 1 | b Elsevier,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB). We determined the developmental toxicity profile of ultrapure PCB 180 in developing offspring following in utero and lactational exposure with the focus on endocrine, metabolic and retinoid system alterations. Pregnant rats were given total doses of 0, 10, 30, 100, 300 or 1000 mg PCB 180/kg bw on gestational days 7-10 by oral gavage, and the offspring were sampled on postnatal days (PND) 7, 35 and 84. Decreased serum testosterone and triiodothyronine concentrations on PND 84, altered liver retinoid levels, increased liver weights and induced 7-pentoxyresorufin O-dealkylase (PROD) activity were the sensitive effects used for margin of exposure (MoE) calculations. Liver weights were increased together with induction of the metabolizing enzymes cytochrome P450 (CYP) 2B1, CYP3A1, and CYP1A1. Less sensitive effects included decreased serum estradiol and increased luteinizing hormone levels in females, decreased prostate and seminal vesicle weight and increased pituitary weight in males, increased cortical bone area and thickness of tibial diaphysis in females and decreased cortical bone mineral density in males. Developmental toxicity profiles were partly different in male and female offspring, males being more sensitive to increased liver weight, PROD induction and decreased thyroxine concentrations. MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations do not exceed the estimated tolerable human lipid-based PCB 180 concentration. Although PCB 180 is much less potent than dioxin-like compounds, it shares several toxicological targets suggesting a potential for interactions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a PCB 180 | |
653 | a Non-dioxin-like PCBs | |
653 | a Testosterone | |
653 | a Thyroid hormones | |
653 | a Retinoid | |
653 | a Endocrine disruption | |
653 | a Liver | |
700 | 1 | a Esteban, Javieru Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 aut |
700 | 1 | a Roos, Robertu Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Grand Duchy Luxembourg, Lab & Mine Inspect, Minist Work, Luxembourg, Luxembourg4 aut |
700 | 1 | a Heikkinen, Paiviu Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland4 aut |
700 | 1 | a Sanchez-Perez, Ismaelu Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 aut |
700 | 1 | a Adamsson, Annikau Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland,Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland,Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands4 aut |
700 | 1 | a Toppari, Jormau Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland4 aut |
700 | 1 | a Koskela, Anttiu Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland4 aut |
700 | 1 | a Finnila, Mikko A. J.u Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland4 aut |
700 | 1 | a Tuukkanen, Juhau Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland4 aut |
700 | 1 | a Herlin, Mariau Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut |
700 | 1 | a Hamscher, Gerdu Justus Liebig Univ, Inst Food Chem & Food Biotechnol, D-35392 Giessen, Germany4 aut |
700 | 1 | a Leslie, Heather A.u Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands4 aut |
700 | 1 | a Korkalainen, Merjau Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland4 aut |
700 | 1 | a Halldin, Kristeru Uppsala universitet,Institutionen för kemi - BMC,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut0 (Swepub:uu)krishall |
700 | 1 | a Schrenk, Dieteru Univ Kaiserslautern, Food Chem & Toxicol, D-67663 Kaiserslautern, Germany4 aut |
700 | 1 | a Hakansson, Helenu Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut |
700 | 1 | a Viluksela, Mattiu Univ Eastern Finland, Sch Pharm Toxicol, Dept Environm & Biol Sci, Kuopio, Finland.;Uppsala Univ, BMC, Off Med & Pharm, SE-75123 Uppsala, Sweden4 aut |
710 | 2 | a Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Swedenb Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain4 org |
773 | 0 | t Reproductive Toxicologyd : Elsevierg 102, s. 109-127q 102<109-127x 0890-6238x 1873-1708 |
856 | 4 | u https://doi.org/10.1016/j.reprotox.2021.04.004y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1587086/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.reprotox.2021.04.004 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447923 |
856 | 4 8 | u https://doi.org/10.1016/j.reprotox.2021.04.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146778306 |
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