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Risk of cardiovascu...
Risk of cardiovascular events in men on abiraterone or enzalutamide combined with GnRH agonists : nation-wide, population-based cohort study in Sweden
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- George, Gincy (författare)
- Kings Coll Londo, Translat Oncol & Urol Res, London, England,Translational Oncology and Urology Research, King’s College Londo, London, United Kingdom
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- Vikman, Hanna (författare)
- Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Gedeborg, Rolf (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Franck Lissbrant, Ingela (författare)
- Univ Göteborg, Sahlgrenska Acad, Dept Oncol, Inst Clin Sci, Gothenburg, Sweden,Institute of Clinical Sciences, Department of Oncology, Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden
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- Garmo, Hans (författare)
- Uppsala universitet,Urologkirurgi,Uppsala Univ Hosp, Reg Canc Ctr Uppsala Örebro, Uppsala, Sweden,Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden; Regional Cancer Centre Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden
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- Styrke, Johan (författare)
- Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden
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- Van Hemelrijck, Mieke (författare)
- Kings Coll Londo, Translat Oncol & Urol Res, London, England,Translational Oncology and Urology Research, King’s College Londo, London, United Kingdom
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Taylor & Francis, 2021
- 2021
- Engelska.
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 60:4, s. 459-465
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundMen with prostate cancer (PCa) on gonadotropin-releasing hormone agonists (GnRH) have an increased risk of cardiovascular disease (CVD) compared to men with PCa not on GnRH as well as compared with PCa-free men. Whether the addition of androgen receptor targeted (ART) drugs to GnRH further increases CVD risk, remains to be fully elucidated.Material and methodsWe investigated risk of CVD for men with castration resistant PCa (CRPC) on GnRH plus ART; abiraterone or enzalutamide vs 5,127 and 12,079 respective matched comparator men on GnRH in Prostate Cancer data Base Sweden (PCBaSeTraject) 4.1 between 1 June 2015 and 31 December 2018. PCBaSeTraject links National Prostate Cancer Register of Sweden to other healthcare registries and demographic databases. We conducted multivariable Cox proportional hazard models adjusting for PCa risk category, Charlson comorbidity index (CCI), insulin or statin use, civil status, level of education, history of CVD events and number of CVD drugs, with any incident or fatal CVD as the outcome.Results and conclusion1,310 men were treated with abiraterone and 3,579 with enzalutamide. In multivariable analysis, CVD risk was increased in men on abiraterone (hazard ratio (HR): 1.19; 95% confidence interval (CI): 1.03–1.38) and in men on enzalutamide (HR: 1.10; 95% CI: 1.01–1.20). Men with a recent CVD (<12 months) including both men on ART as well as comparators had a much higher probability of a new CVD vs men with no prior CVD. CVD risk was mildly increased in men with PCa on GnRH plus abiraterone or enzalutamide vs comparator men on GnRH. Residual confounding and detection bias may at least partly explain this association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Prostate cancer
- abiraterone
- enzalutamide
- GnRH agonists
- cardiovascular events
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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