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  • Remes, Tiina M.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (författare)

Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-01-22
  • Oxford University Press,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-448797
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448797URI
  • https://doi.org/10.1093/nop/npab004DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:234055374URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundLittle is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.MethodsNeurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.ResultsSurvivors’ (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.ConclusionsRadiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hovén, EmmaKarolinska Institutet (författare)
  • Ritari, NiinaUniv Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (författare)
  • Pohjasniemi, HeliOulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Puosi, RiinaUniv Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (författare)
  • Arikoski, Pekka M.Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland (författare)
  • Arola, Mikko O.Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland (författare)
  • Lähteenmäki, Päivi M.Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland (författare)
  • Lönnqvist, Tuula R. I.Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (författare)
  • Ojaniemi, Marja K.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Riikonen, V. PekkaUniv Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland (författare)
  • Sirkiä, Kirsti H.Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland (författare)
  • Winqvist, SatuOulu Univ Hosp, Dept Neurol, Oulu, Finland (författare)
  • Rantala, Heikki M. J.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Harila, MarikaOulu Univ Hosp, Dept Neurol, Oulu, Finland (författare)
  • Harila-Saari, Arja H.Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456 (författare)
  • Karolinska InstitutetOulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neuro-Oncology Practice: Oxford University Press8:3, s. 266-2772054-25772054-2585

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