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The Mastigamoeba ba...
The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba
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- Zarsky, Vojtech (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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- Klimes, Vladimir (författare)
- Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic.
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- Paces, Jan (författare)
- Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.
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- Vlcek, Cestmir (författare)
- Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.
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- Hradilova, Miluse (författare)
- Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.
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- Benes, Vladimir (författare)
- European Mol Biol Lab EMBL, Genom Core Facil, Heidelberg, Germany.
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- Nyvltova, Eva (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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- Hrdy, Ivan (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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- Pyrih, Jan (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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- Mach, Jan (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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- Barlow, Lael (författare)
- Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.
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- Stairs, Courtney W. (författare)
- Uppsala universitet,Molekylär evolution,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.
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- Eme, Laura (författare)
- Univ Paris Saclay, Divers Ecol & Evolut Microbes DEEM, Unite Ecol Systemat Evolut, Orsay, France.
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- Hall, Neil (författare)
- Earlham Inst, Norwich Res Pk, Norwich, Norfolk, England.;Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, Norfolk, England.
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- Elias, Marek (författare)
- Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic.
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- Dacks, Joel B. (författare)
- Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.;Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada.;CAS vvi, Inst Parasitol, Biol Ctr, Ceske Budejovice, Czech Republic.
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- Roger, Andrew (författare)
- Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.
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- Tachezy, Jan (författare)
- Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.
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Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic. (creator_code:org_t)
- 2021-02-02
- 2021
- Engelska.
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Ingår i: Molecular biology and evolution. - : Oxford University Press. - 0737-4038 .- 1537-1719. ; 38:6, s. 2240-2259
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Abstract
Ämnesord
Stäng
- The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic free-living Mastigamoeba balamuthi and performed phylogenomic analysis of four related members of the Archamoebae, including Entamoeba histolytica, an important intestinal pathogen of humans. We aimed to trace gene histories throughout the adaptation of the aerobic ancestor of Archamoebae to anaerobiosis and throughout the transition from a free-living to a parasitic lifestyle. These events were associated with massive gene losses that, in parasitic lineages, resulted in a reduction in structural features, complete losses of some metabolic pathways, and a reduction in metabolic complexity. By reconstructing the features of the common ancestor of Archamoebae, we estimated preconditions for the evolution of parasitism in this lineage. The ancestor could apparently form chitinous cysts, possessed proteolytic enzyme machinery, compartmentalized the sulfate activation pathway in mitochondrion-related organelles, and possessed the components for anaerobic energy metabolism. After the split of Entamoebidae, this lineage gained genes encoding surface membrane proteins that are involved in host-parasite interactions. In contrast, gene gains identified in the M. balamuthi lineage were predominantly associated with polysaccharide catabolic processes. A phylogenetic analysis of acquired genes suggested an essential role of lateral gene transfer in parasite evolution (Entamoeba) and in adaptation to anaerobic aquatic sediments (Mastigamoeba).
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- evolution of parasitism
- lateral gene transfer
- pathway complexity
- Archamoebae
- chitinous cysts
- Mastigamoeba
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zarsky, Vojtech
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Klimes, Vladimir
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Paces, Jan
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Vlcek, Cestmir
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Hradilova, Milus ...
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Benes, Vladimir
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visa fler...
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Nyvltova, Eva
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Hrdy, Ivan
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Pyrih, Jan
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Mach, Jan
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Barlow, Lael
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Stairs, Courtney ...
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Eme, Laura
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Hall, Neil
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Elias, Marek
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Dacks, Joel B.
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Roger, Andrew
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Tachezy, Jan
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Evolutionsbiolog ...
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Molecular biolog ...
- Av lärosätet
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Uppsala universitet