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Utilizing Laser Act...
Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet
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- Hempel, Nele-Johanna (författare)
- Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark.
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- Merkl, Padryk (författare)
- Karolinska Institutet
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- Asad, Shno (författare)
- Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab
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- Knopp, Matthias Manne (författare)
- Bioneer FARMA, Dept Pharm, DK-2100 Copenhagen, Denmark.
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- Berthelsen, Ragna (författare)
- Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark.
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- Bergström, Christel, 1973- (författare)
- Uppsala universitet,Institutionen för farmaci
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- Teleki, Alexandra (författare)
- Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab
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- Sotiriou, Georgios A. (författare)
- Karolinska Institutet
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- Löbmann, Korbinian (författare)
- Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark.
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Karolinska Institutet Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark (creator_code:org_t)
- 2021-05-05
- 2021
- Engelska.
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Ingår i: Molecular Pharmaceutics. - : American Chemical Society (ACS). - 1543-8384 .- 1543-8392. ; 18:6, s. 2254-2262
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm(-2) laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- plasmonic nanoaggregates
- near-IR laser irradiation
- in situ drug amorphization
- amorphous solid dispersions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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