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SARS-CoV-2 Spike Pr...
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Malik, Yashpal S.ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.;Guru Angad Dev Vet & Anim Sci Univ, Coll Anim Biotechnol, Ludhiana, Punjab, India.
(författare)
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-07-28
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Frontiers Media S.A.2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-452780
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452780URI
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https://doi.org/10.3389/fmolb.2021.607886DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kumar, PrashantAmity Univ, Amity Inst Virol & Immunol, Noida, India.
(författare)
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Ansari, Mohd IkramICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.;Integral Univ, Dept Biosci, Lucknow, Uttar Pradesh, India.
(författare)
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Hemida, Maged G.King Faisal Univ, Coll Vet Med, Dept Microbiol, Al Hufuf, Saudi Arabia.;Kafrelsheikh Univ, Fac Vet Med, Dept Virol, Kafr El Shaikh, Egypt.
(författare)
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El Zowalaty, Mohamed E.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
(författare)
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Abdel-Moneim, Ahmed S.Taif Univ, Coll Med, Microbiol Dept, Al Taif, Saudi Arabia.;Beni Suef Univ, Fac Vet Med, Virol Dept, Bani Suwayf, Egypt.
(författare)
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Ganesh, BalasubramanianMinist Hlth & Family Welf, Natl Inst Epidemiol, Indian Council Med Res, Lab Div, Chennai, Tamil Nadu, India.
(författare)
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Salajegheh, SinaIslamic Azad Univ, Sci & Res Branch, Young Researchers & Elites Club, Tehran, Iran.;Islamic Azad Univ, Sci & Res Branch, Fac Vet Med, Tehran, Iran.
(författare)
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Natesan, SenthilkumarIndian Inst Publ Hlth Gandhinagar, Gandhinagar, India.
(författare)
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Sircar, ShubhankarICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.
(författare)
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Safdar, MuhammadCholistan Univ Vet & Anim Sci, Dept Breeding & Genet, Bahawalpur, Pakistan.
(författare)
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Vinodhkumar, O. R.ICAR Indian Vet Res Inst, Div Epidemiol, Bareilly, Uttar Pradesh, India.
(författare)
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Duarte, Phelipe M.Univ Cuiaba, Fac Biol & Hlth Sci, Primavera Do Leste, Brazil.
(författare)
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Patel, Shailesh K.ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India.
(författare)
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Klein, JornUniv Cuiaba, Fac Biol & Hlth Sci, Primavera Do Leste, Brazil.;Univ South Eastern Norway, Fac Hlth & Social Sci, Kongsberg, Norway.
(författare)
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Rahimi, ParastooIslamic Azad Univ, Sci & Res Branch, Fac Vet Med, Tehran, Iran.
(författare)
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Dhama, KuldeepICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India.
(författare)
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ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India.;Guru Angad Dev Vet & Anim Sci Univ, Coll Anim Biotechnol, Ludhiana, Punjab, India.Amity Univ, Amity Inst Virol & Immunol, Noida, India.
(creator_code:org_t)
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Ingår i:Frontiers in Molecular Biosciences: Frontiers Media S.A.82296-889X
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Malik, Yashpal S ...
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Kumar, Prashant
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Ansari, Mohd Ikr ...
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Hemida, Maged G.
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El Zowalaty, Moh ...
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Abdel-Moneim, Ah ...
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visa fler...
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Ganesh, Balasubr ...
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Salajegheh, Sina
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Natesan, Senthil ...
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Sircar, Shubhank ...
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Safdar, Muhammad
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Vinodhkumar, O. ...
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Duarte, Phelipe ...
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Patel, Shailesh ...
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Klein, Jorn
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Rahimi, Parastoo
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Dhama, Kuldeep
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