Sökning: onr:"swepub:oai:DiVA.org:uu-453041" > Toll-like receptor ...
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000 | 05591naa a2200505 4500 | |
001 | oai:DiVA.org:uu-453041 | |
003 | SwePub | |
008 | 210920s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4530412 URI |
024 | 7 | a https://doi.org/10.1038/s41398-021-01481-w2 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rasmusson, Annica J.u Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)annijaco |
245 | 1 0 | a Toll-like receptor 4 methylation grade is linked to depressive symptom severity |
264 | c 2021-06-24 | |
264 | 1 | b Springer Nature,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a This study explores potential associations between the methylation of promoter-associated CpG sites of the toll-like receptor (TLR)-family, plasma levels of pro-inflammatory proteins and depressive symptoms in young female psychiatric patients. Ratings of depressive symptoms and blood samples were obtained from 92 young women seeking psychiatric care. Methylation of 32 promoter-associated CpG sites in TLR1 to TLR10 was analysed using the Illumina Infinium Methylation EPIC BeadChip. Expression levels of 91 inflammatory proteins were determined by proximity extension assay. Statistical correlations between depressive state, TLR1-10 methylation and inflammatory proteins were investigated. Four additional cohorts were studied to evaluate the generalizability of the findings. In the discovery cohort, methylation grade of cg05429895 (TLR4) in blood was inversely correlated with depressive symptoms score in young adults. After correction for multiple testing, plasma levels of macrophage inflammatory protein 1 beta (MIP-1 beta/CCL4) were associated with both TLR4 methylation and depressive symptom severity. A similar inverse association between TLR4 methylation in blood and affective symptoms score was also found in a cohort of 148 both males and females (<40 years of age) from the Danish Twin Registry. These findings were not, however, replicated in three other external cohorts; which differed from the first two cohorts by a higher age and mixed ethnicities, thus limiting the generalizability of our findings. However, TLR4 methylation inversely correlated with TLR4 mRNA expression in the Danish Twin Study indicating a functional significance of methylation at this particular CpG. Higher depression scores in young Scandinavian adults was associated with decreased methylation of TLR4 in blood. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Gallwitz, Maikeu Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)magal613 |
700 | 1 | a Soltanabadi, Bardiau Uppsala universitet,Cervenka: Psykiatri4 aut |
700 | 1 | a Ciuculete, Diana-Mariau Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)diaci119 |
700 | 1 | a Mengel-From, Jonasu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.4 aut |
700 | 1 | a Christensen, Kaareu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.;Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark.4 aut |
700 | 1 | a Nygaard, Marianneu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.4 aut |
700 | 1 | a Soerensen, Metteu Univ Southern Denmark, Danish Twin Registry, Epidemiol Biostat & Biodemog, Dept Publ Hlth, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.;Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark.4 aut |
700 | 1 | a Boström, Adrian,d 1990-u Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)adrbo331 |
700 | 1 | a Fredriksson, Robertu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)rfr20930 |
700 | 1 | a Freyhult, Eva,d 1979-u Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)evfre192 |
700 | 1 | a Mwinyi, Jessicau Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)jesmw847 |
700 | 1 | a Czamara, Darinau Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.4 aut |
700 | 1 | a Binder, Elisabeth B.u Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.4 aut |
700 | 1 | a Schiöth, Helgi B.u Uppsala universitet,Schiöth: Funktionell farmakologi,IM Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia.4 aut0 (Swepub:uu)helgschi |
700 | 1 | a Cunningham, Janetu Uppsala universitet,Cervenka: Psykiatri4 aut0 (Swepub:uu)janecunn |
710 | 2 | a Uppsala universitetb Cervenka: Psykiatri4 org |
773 | 0 | t Translational Psychiatryd : Springer Natureg 11q 11x 2158-3188 |
856 | 4 | u https://doi.org/10.1038/s41398-021-01481-wy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1595487/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41398-021-01481-w.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453041 |
856 | 4 8 | u https://doi.org/10.1038/s41398-021-01481-w |
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