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Neuronal and glial ...
Neuronal and glial CSF biomarkers in multiple sclerosis : a systematic review and meta-analysis
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- Momtazmanesh, Sara (författare)
- Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran; Univ Tehran Med Sci, Childrens Med Ctr Hosp, Sch Med, Dr Qarib St,Keshavarz Blvd, Tehran 14194, Iran; Universal Sci Educ & Res Network USERN, Systemat Review & Meta Anal Expert Grp SRMEG, Tehran, Iran
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- Shobeiri, Parnian (författare)
- Univ Tehran Med Sci, Childrens Med Ctr Hosp, Sch Med, Dr Qarib St, Keshavarz Blvd, Tehran 14194, Iran; Universal Sci Educ & Res Network USERN, Systemat Review & Meta Anal Expert Grp SRMEG, Tehran, Iran
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- Saghazadeh, Amene (författare)
- Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran; Universal Sci Educ & Res Network USERN, Systemat Review & Meta Anal Expert Grp SRMEG, Tehran, Iran
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- Teunissen, Charlotte E. (författare)
- Locat VUmc, Neurochem Lab, Dept Clin Chem, PK 2 BR 141,Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
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- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Szalardy, Levente (författare)
- Univ Szeged, Fac Med, Albert Szent Gyorgyi Clin Ctr, Dept Neurol, Semmelweis U 6, H-6725 Szeged, Hungary
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- Klivenyi, Peter (författare)
- Univ Szeged, Fac Med, Albert Szent Gyorgyi Clin Ctr, Dept Neurol, Semmelweis U 6, H-6725 Szeged, Hungary
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- Bartos, Ales (författare)
- Charles Univ Prague, Fac Med 3, Dept Neurol, Ruska 87, Prague 10000 10, Czech Republic
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- Fernandes, Adelaide (författare)
- Univ Lisbon, Fac Pharm, Dept Pharmacol Sci & Med, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal
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- Rezaei, Nima (författare)
- Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran; Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran; Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran
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(creator_code:org_t)
- 2021-02-17
- 2021
- Engelska.
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Ingår i: Reviews in the Neurosciences. - : Walter de Gruyter GmbH. - 0334-1763 .- 2191-0200. ; 32:6, s. 573-595
- Relaterad länk:
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https://www.degruyte...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Multiple sclerosis (MS) is a neurodegenerative disease associated with inflammatory demyelination and astroglial activation, with neuronal and axonal damage as the leading factors of disability. We aimed to perform a meta-analysis to determine changes in CSF levels of neuronal and glial biomarkers, including neurofilament light chain (NFL), total tau (t-tau), chitinase-3-like protein 1 (CHI3L1), glial fibrillary acidic protein (GFAP), and S100B in various groups of MS (MS versus controls, clinically isolated syndrome (CIS) versus controls, CIS versus MS, relapsing-remitting MS (RRMS) versus progressive MS (PMS), and MS in relapse versus remission. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we included 64 articles in the metaanalysis, including 4071 subjects. For investigation of sources of heterogeneity, subgroup analysis, metaregression, and sensitivity analysis were conducted. Meta-analyses were performed for comparisons including at least three individual datasets. NFL, GFAP, t-tau, CHI3L1, and S100B were higher in MS and NFL, t-tau, and CHI3L1 were also elevated in CIS patients than controls. CHI3L1 was the only marker with higher levels in MS than CIS. GFAP levels were higher in PMS versus RRMS, and NFL, t-tau, and CHI3L1 did not differ between different subtypes. Only levels of NFL were higher in patients in relapse than remission. Meta-regression showed influence of sex and disease severity on NFL and t-tau levels, respectively and disease duration on both. Added to the role of these biomarkers in determining prognosis and treatment response, to conclude, they may serve in diagnosis of MS and distinguishing different subtypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- chitinase-3-like protein 1
- diagnosis
- glial fibrillary acidic protein
- neurofilament protein light
- tau protein
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Momtazmanesh, Sa ...
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Shobeiri, Parnia ...
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Saghazadeh, Amen ...
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Teunissen, Charl ...
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Burman, Joachim, ...
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Szalardy, Levent ...
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Klivenyi, Peter
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Bartos, Ales
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Fernandes, Adela ...
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Rezaei, Nima
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Reviews in the N ...
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Uppsala universitet