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Risk factors for re...
Risk factors for residual disease at re-TUR in a large cohort of T1G3 patients
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- Pisano, F. (author)
- Univ Studies Turin, Citta Salute & Sci Torino, Turin, Italy.;Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.
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- Gontero, P. (author)
- Univ Studies Turin, Citta Salute & Sci Torino, Turin, Italy.
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- Sylvester, R. (author)
- EORTC Headquarters, Dept Biostat, Brussels, Belgium.
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- Joniau, S. (author)
- Univ Hosp Leuven, Dept Urol, Oncol & Reconstruct Urol, Leuven, Belgium.
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- Serretta, V (author)
- Univ Palermo, Dept Surg Oncol & Stomatol Sci, Palermo, Italy.
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- Larre, S. (author)
- Univ Oxford, John Radcliffe Hosp, Dept Surg Sci, Oxford, England.
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- Di Stasi, S. (author)
- Policlin Tor Vergata Univ Rome, Rome, Italy.
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- van Rhijn, B. (author)
- Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Urol, Amsterdam, Netherlands.
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- Witjes, A. (author)
- Radboud Univ Nijmegen, Dept Urol, Med Ctr, Nijmegen, Netherlands.
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- Grotenhuis, A. (author)
- Radboud Univ Nijmegen, Dept Urol, Med Ctr, Nijmegen, Netherlands.
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- Colombo, R. (author)
- Univ Vita Salute, Dipartimento Urol, Osped S Raffaele, Milan, Italy.
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- Briganti, A. (author)
- Univ Vita Salute, Dipartimento Urol, Osped S Raffaele, Milan, Italy.
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- Babjuk, M. (author)
- Univ Praha, Motol Hosp, Dept Urol, Prague, Czech Republic.
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- Soukup, V (author)
- Univ Praha, Motol Hosp, Dept Urol, Prague, Czech Republic.
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- Malmström, Per-Uno (author)
- Uppsala universitet,Urologkirurgi
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- Irani, J. (author)
- Hosp Bicetre, Dept Urol, Le Kremlin Bicetre, France.
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- Malats, N. (author)
- Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.
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- Baniel, J. (author)
- Rabin Med Ctr, Dept Urol, Tel Aviv, Israel.
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- Mano, R. (author)
- Rabin Med Ctr, Dept Urol, Tel Aviv, Israel.
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- Cai, T. (author)
- Santa Chiara Hosp, Dept Urol, Trento, Italy.
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- Cha, E. (author)
- Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
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- Ardelt, P. (author)
- Univ Hosp Basel, Urol Univ Clin Basel Liestal, Basel, Switzerland.
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- Varkarakis, J. (author)
- Univ Athens, Sismanoglio Hosp, Dept Urol, Athens, Greece.
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- Bartoletti, R. (author)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy.
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- Dalbagni, G. (author)
- Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
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- Shariat, S. F. (author)
- Med Univ Vienna, Dept Urol, A-1190 Vienna, Austria.;Cochin Hosp, Dept Urol, Paris, France.
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- Xylinas, E. (author)
- Mayo Clin, Dept Urol, Rochester, MN USA.
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- Karnes, R. J. (author)
- Mayo Clin, Dept Urol, Rochester, MN USA.
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- Palou, J. (author)
- Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.
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Univ Studies Turin, Citta Salute & Sci Torino, Turin, Italy;Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain. Univ Studies Turin, Citta Salute & Sci Torino, Turin, Italy. (creator_code:org_t)
- ENE EDICIONES SL, 2021
- 2021
- English.
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In: Actas Urológicas Españolas. - : ENE EDICIONES SL. - 0210-4806 .- 1699-7980. ; 45:6, s. 473-478
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction and objectives: The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis in order to adequately stage the patient. It is well known that the presence of detrusor muscle in the specimen is a prerequisite to minimize the risk of under staging. Persistent disease after resection of bladder tumors is not uncommon and is the reason why the European Guidelines recommended a re-TUR for all T1 tumors. It was recently published that when there is muscle in the specimen, re-TUR does not influence progression or cancer specific survival. We present here the patient and tumor factors that may influence the presence of residual disease at re-TUR.Material and methods: In our retrospective cohort of 2451 primary T1G3 patients initially treated with BCG, pathology results for 934 patients (38.1%) who underwent re-TUR are available. 74% had multifocal tumors, 20% of tumors were more than 3 cm in diameter and 26% had concomitant CIS. In this subgroup of patients who underwent re-TUR, there was no residual disease in 267 patients (29%) and residual disease in 667 patients (71%): Ta in 378 (40%) and T1 in 289 (31%) patients. Age, gender, tumor status (primary/recurrent), previous intravesical therapy, tumor size, tumor multi-focality, presence of concomitant CIS, and muscle in the specimen were analyzed in order to evaluate risk factors of residual disease at re-TUR, both in univariate analyses and multivariate logistic regressions.Results: The following were not risk factors for residual disease: age, gender, tumor status and previous intravesical chemotherapy. The following were univariate risk factors for presence of residual disease: no muscle in TUR, multiple tumors, tumors >= 3 cm, and presence of concomitant CIS. Due to the correlation between tumor multi-focality and tumor size, the multivariate model retained either the number of tumors or the tumor diameter (but not both), p < 0.001. The presence of muscle in the specimen was no longer significant, while the presence of CIS only remained significant in the model with tumor size, p < 0.001.Conclusions: The most significant factors for a higher risk of residual disease at re-TUR in T1G3 patients are multifocal tumors and tumors more than 3 cm. Patients with concomitant CIS and those without muscle in the specimen also have a higher risk of residual disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Non-muscle invasive bladder cancer
- Re-transurethral resection of the bladder
- Residual disease
- Recurrence
- Progression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pisano, F.
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Gontero, P.
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Sylvester, R.
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Joniau, S.
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Serretta, V
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Larre, S.
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show more...
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Di Stasi, S.
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van Rhijn, B.
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Witjes, A.
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Grotenhuis, A.
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Colombo, R.
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Briganti, A.
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Babjuk, M.
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Soukup, V
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Malmström, Per-U ...
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Irani, J.
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Malats, N.
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Baniel, J.
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Mano, R.
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Cai, T.
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Cha, E.
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Ardelt, P.
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Varkarakis, J.
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Bartoletti, R.
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Dalbagni, G.
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Shariat, S. F.
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Xylinas, E.
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Karnes, R. J.
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Palou, J.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Urology and Neph ...
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Uppsala University