Sökning: onr:"swepub:oai:DiVA.org:uu-453897" > Functional differen...
Fältnamn | Indikatorer | Metadata |
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000 | 07127naa a2200589 4500 | |
001 | oai:DiVA.org:uu-453897 | |
003 | SwePub | |
008 | 211004s2021 | |||||||||||000 ||eng| | |
009 | oai:slubar.slu.se:113103 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4538972 URI |
024 | 7 | a https://doi.org/10.1038/s42003-021-02307-72 DOI |
024 | 7 | a https://res.slu.se/id/publ/1131032 URI |
040 | a (SwePub)uud (SwePub)slu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Chen, Junfengu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Nagoya Univ, Inst Transformat Biomol ITbM, Lab Anim Integrat Physiol, Grad Sch Bioagr Sci, Nagoya, Japan.4 aut |
245 | 1 0 | a Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring |
264 | c 2021-06-25 | |
264 | 1 | b Springer Nature,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a The underlying molecular mechanisms that determine long day versus short day breeders remain unknown in any organism. Atlantic herring provides a unique opportunity to examine the molecular mechanisms involved in reproduction timing, because both spring and autumn spawners exist within the same species. Although our previous whole genome comparisons revealed a strong association of TSHR alleles with spawning seasons, the functional consequences of these variants remain unknown. Here we examined the functional significance of six candidate TSHR mutations strongly associated with herring reproductive seasonality. We show that the L471M missense mutation in the spring-allele causes enhanced cAMP signaling. The best candidate non-coding mutation is a 5.2kb retrotransposon insertion upstream of the TSHR transcription start site, near an open chromatin region, which is likely to affect TSHR expression. The insertion occurred prior to the split between Pacific and Atlantic herring and was lost in the autumn-allele. Our study shows that strongly associated coding and non-coding variants at the TSHR locus may both contribute to the regulation of seasonal reproduction in herring. Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring-allele is correlated with enhanced cAMP signaling and that both coding and non-coding variants in the TSHR locus contribute to seasonal reproduction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Fisk- och akvakulturforskning0 (SwePub)401072 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Fish and Aquacultural Science0 (SwePub)401072 hsv//eng |
700 | 1 | a Bi, Huijuanu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut |
700 | 1 | a Pettersson, Matsu Uppsala universitet,Molekylär evolution,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)mapet205 |
700 | 1 | a Sato, Daikiu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi, Japan.4 aut |
700 | 1 | a Fuentes Pardo, Angela P.u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)angfu103 |
700 | 1 | a Mo, Chunhengu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China.4 aut |
700 | 1 | a Younis, Shadyu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Stanford Univ, Div Immunol & Rheumatol, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)shayo804 |
700 | 1 | a Wallerman, Olau Uppsala universitet,Institutionen för genetik och patologi,Medicinsk genetik,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Genomik,Medicinsk genetik och genomik4 aut0 (Swepub:uu)olwal516 |
700 | 1 | a Jern, Patricu Uppsala universitet,Klinisk virologi,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)patrjern |
700 | 1 | a Moles, Gregoriou CSIC, Dept Fish Physiol & Biotechnol, Inst Acuicultura Torre Sal, Castellon de La Plana, Spain.4 aut |
700 | 1 | a Gomez, Anau CSIC, Dept Fish Physiol & Biotechnol, Inst Acuicultura Torre Sal, Castellon de La Plana, Spain.4 aut |
700 | 1 | a Kleinau, Gunnaru Charite, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Inst Med Phys & Biophys CC2, Grp Prot Xray Crystallog & Signal Transduct, Berlin, Germany.4 aut |
700 | 1 | a Scheerer, Patricku Charite, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Inst Med Phys & Biophys CC2, Grp Prot Xray Crystallog & Signal Transduct, Berlin, Germany.4 aut |
700 | 1 | a Andersson, Leifu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Genomik,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.;Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University4 aut0 (Swepub:slu)48730 |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t Communications Biologyd : Springer Natureg 4:1q 4:1x 2399-3642 |
856 | 4 | u https://doi.org/10.1038/s42003-021-02307-7y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1600188/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s42003-021-02307-7.pdf |
856 | 4 | u https://pub.epsilon.slu.se/id/eprint/25064/contentsx primaryx Raw objectx freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453897 |
856 | 4 8 | u https://doi.org/10.1038/s42003-021-02307-7 |
856 | 4 8 | u https://res.slu.se/id/publ/113103 |
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