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Effects of oral app...
Effects of oral appliance treatment on inflammatory biomarkers in obstructive sleep apnea : A randomised controlled trial
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- Hedberg, Pär (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Västerås, Sweden.,Department of Clinical Physiology, Västmanland County Hospital, Västerås, Sweden; Centre for Clinical Research, Uppsala University, Västerås, Sweden
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- Nohlert, Eva, 1955- (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Västerås, Sweden
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- Tegelberg, Åke (författare)
- Malmö universitet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Malmö Univ, Fac Odontol, Dept Orofacial Pain & Jaw Funct, Malmö, Sweden.,Odontologiska fakulteten (OD),Centre for Clinical Research, Uppsala University, Västerås, Sweden
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(creator_code:org_t)
- 2020-12-09
- 2021
- Engelska.
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Ingår i: Journal of Sleep Research. - : John Wiley & Sons. - 0962-1105 .- 1365-2869. ; 30:4
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Abstract
Ämnesord
Stäng
- Obstructive sleep apnea (OSA) may lead to increased circulating concentrations of inflammatory biomarkers and treatment may change these. We aimed to assess the effect of oral appliance (OA) therapy on inflammatory biomarkers in a randomised controlled pilot trial. A total of 71 patients with OSA and systemic hypertension were randomly allocated to an active, mandible protruded (OAa) or a passive, mandible non-protruded device (OAp) treatment. Serum concentrations of the inflammatory biomarkers white blood cells, high-sensitivity C-reactive protein, interleukin 6, interleukin 10, and tumour necrosis factor-alpha were measured at baseline and after 3 months of OA treatment. The differences between treatment groups in biomarker concentration change during the treatment were presented as the Vargha and Delaney effect size and evaluated with the Wilcoxon-Mann-Whitney test. This effect size expresses the probability of a higher value in a random participant from one group compared with a random patient from the other group, and a value of 0.5 means stochastically equal groups. After 3 months of treatment, there was a significant reduction of the apnea-hypopnea index in the OAa group compared with the OAp group (effect size 0.258, 95% confidence interval 0.146-0.386, p < .001). There were no significant differences between the groups in any of the inflammatory markers' concentration changes during the treatment period (effect sizes between 0.488 and 0.524; all p values >=.737). Thus, OA treatment for 3 months did not affect circulating concentrations of some common inflammatory markers in patients with OSA and systemic hypertension.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- C‐
- reactive protein
- inflammation
- interleukins
- mandibular advancement device
- obstructive sleep apnea
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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