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Conserved and conte...
Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development
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- Ando, Koji (författare)
- Uppsala universitet,Vaskulärbiologi,Nippon Med Sch, Inst Adv Med Sci, Dept Mol Pathophysiol, Bunkyo Ku, Tokyo 1138602, Japan
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- Shih, Yu-Huan (författare)
- Univ Massachusetts, Dept Mol Cell & Canc Biol, Med Sch, Worcester, MA 01650 USA
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- Ebarasi, Lwaki (författare)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, Stockholm, Sweden
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- Grosse, Ann (författare)
- Univ Massachusetts, Dept Mol Cell & Canc Biol, Med Sch, Worcester, MA 01650 USA
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- Portman, Daneal (författare)
- Univ Massachusetts, Dept Mol Cell & Canc Biol, Med Sch, Worcester, MA 01650 USA
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- Chiba, Ayano (författare)
- Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Cell Biol, Suita, Osaka 5648565, Japan
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- Mattonet, Kenny (författare)
- Max Planck Inst Heart & Lung Res, Dept Dev Genet, Ludwigstr 43, D-61231 Bad Nauheim, Germany
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- Gerri, Claudia (författare)
- Max Planck Inst Heart & Lung Res, Dept Dev Genet, Ludwigstr 43, D-61231 Bad Nauheim, Germany; Francis Crick Inst, Human Embryo & Stem Cell Lab, 1 Midland Rd, London NW1 1AT, England
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- Stainier, Didier Y. R. (författare)
- Max Planck Inst Heart & Lung Res, Dept Dev Genet, Ludwigstr 43, D-61231 Bad Nauheim, Germany
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- Mochizuki, Naoki (författare)
- Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Cell Biol, Suita, Osaka 5648565, Japan
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- Fukuhara, Shigetomo (författare)
- Nippon Med Sch, Inst Adv Med Sci, Dept Mol Pathophysiol, Bunkyo Ku, Tokyo 1138602, Japan
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- Betsholtz, Christer (författare)
- Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Dept Med Huddinge MedH, Neo, Campus Flemingsberg,Blickagagen 16,Hiss S,Plan 7, SE-14157 Huddinge, Sweden
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- Lawson, Nathan D. (författare)
- Univ Massachusetts, Dept Mol Cell & Canc Biol, Med Sch, Worcester, MA 01650 USA
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Developmental Biology. - : Elsevier. - 0012-1606 .- 1095-564X. ; 479, s. 11-22
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Platelet derived growth factor beta and its receptor, Pdgfrb, play essential roles in the development of vascular mural cells, including pericytes and vascular smooth muscle cells. To determine if this role was conserved in zebrafish, we analyzed pdgfb and pdgfrb mutant lines. Similar to mouse, pdgfb and pdgfrb mutant zebrafish lack brain pericytes and exhibit anatomically selective loss of vascular smooth muscle coverage. Despite these defects, pdgfrb mutant zebrafish did not otherwise exhibit circulatory defects at larval stages. However, beginning at juvenile stages, we observed severe cranial hemorrhage and vessel dilation associated with loss of pericytes and vascular smooth muscle cells in pdgfrb mutants. Similar to mouse, pdgfrb mutant zebrafish also displayed structural defects in the glomerulus, but normal development of hepatic stellate cells. We also noted defective mural cell investment on coronary vessels with concomitant defects in their development. Together, our studies support a conserved requirement for Pdgfrb signaling in mural cells. In addition, these zebrafish mutants provide an important model for definitive investigation of mural cells during early embryonic stages without confounding secondary effects from circulatory defects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Nyckelord
- Pdgfrb
- Mural cells
- Pericytes
- Vascular smooth muscle cells
- Zebrafish
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ando, Koji
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Shih, Yu-Huan
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Ebarasi, Lwaki
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Grosse, Ann
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Portman, Daneal
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Chiba, Ayano
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visa fler...
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Mattonet, Kenny
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Gerri, Claudia
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Stainier, Didier ...
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Mochizuki, Naoki
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Fukuhara, Shiget ...
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Betsholtz, Chris ...
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Lawson, Nathan D ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Utvecklingsbiolo ...
- Artiklar i publikationen
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Developmental Bi ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet