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HLA-B*27 is signifi...
HLA-B*27 is significantly enriched in Nordic patients with psoriatic arthritis mutilans
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- Nikamo, P. (författare)
- Karolinska Institutet
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- Gudbjornsson, B. (författare)
- Univ Iceland, Landspitali Univ Hosp, Ctr Rheumatol Res, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Laasonen, L. (författare)
- Karolinska Institutet
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- Ejstrup, L. (författare)
- Odense Univ Hosp, Dept Rheumatol, Odense, Denmark.
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- Iversen, L. (författare)
- Aarhus Univ Hosp, Dept Dermatol, Aarhus, Denmark.
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- Lindqvist, Ulla, 1948- (författare)
- Uppsala universitet,Reumatologi
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- Padyukov, L. (författare)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Ståhle, M. (författare)
- Karolinska Institutet
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Karolinska Institutet Univ Iceland, Landspitali Univ Hosp, Ctr Rheumatol Res, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland. (creator_code:org_t)
- CLINICAL & EXPER RHEUMATOLOGY, 2021
- 2021
- Engelska.
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Ingår i: Clinical and Experimental Rheumatology. - : CLINICAL & EXPER RHEUMATOLOGY. - 0392-856X .- 1593-098X. ; 39:4, s. 775-780
- Relaterad länk:
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https://www.clinexpr...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Objective The genetic contribution to psoriatic disease is substantial with a dominating influence of the MLA region. The profile of HLA class 1 genotypes likely contributes to shaping clinical phenotypes. Herein we aimed to explore such genotypes in cohorts of closely characterised subsets of psoriatic disease with special focus on psoriatic arthritis mutilans (PAM), a severe and rare form of psoriatic arthritis (PsA). Methods Cohorts of patients with the diagnosis of psoriasis vulgaris with or without arthritis (n=1217), psoriasis without arthritis (n=534), psoriatic arthritis without mutilating disease (n=337) and psoriatic arthritis mutilans (n=63) were collected and genotyped for HLA class 1 and 11 genes, with standardised methodologies. Cases were compared with a healthy control population (n=2468). Case-only and case-control association tests were performed to address the hypothesis of genetic contribution to clinical phenotypes. Results The presence of HLA-B*27 was strikingly increased in PAM (45%) compared with PsA without mutilating disease (13%) and with healthy controls (13%). However, within the PAM population, HLA-B*27 did not correlate with clinical markers such as number of mutilating joints, radiographic scoring, disease duration and age of disease onset. Conclusion HLA-B*27 emerges as an important genotype marker for PAM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- psoriasis
- arthritis
- mutilans
- HLA-B*27
- HLA-genotyping
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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